How It Works
How It Works
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HCG &
Gonadorelin
Human Chorionic Gonadotropin (HCG) is a hormone that mimics the natural effects of Lutenizing Hormone (LH). In men HCG is used to for several indications that include 1) preservation of fertility while on testosterone replacement therapy (TRT) 2) maintain testicular volume while on TRT 3) as a stand-alone medication to improve testosterone levels in hypogonadal males and 4) to improve fertility after a man stops TRT. To learn more about the safety, efficacy and clinical use of HCG, please read the following information below.
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Human Chorionic Gonadotropin (HCG) is an analog of luteinizing hormone (LH). (An analog means it is identical at the molecular level.) Administering HCG to men can stimulate the testicles to produce testosterone.
In men, the anterior pituitary gland produces LH in response to gonadotropic releasing hormone (GnRH) from the hypothalamus. LH acts on the Leydig cells of the testicles, stimulating the testicles to produce intratesticular testosterone and promote spermatogenesis (sperm production).
The U.S. Food & Drug Administration (FDA) has approved the use of HCG in select cases of hypogonadism as a result of a pituitary deficiency (hypogonadotropic hypogonadism) in males. HCG may also be prescribed for off-label use.
The use and administration of exogenous (external) testosterone in men can affect male fertility by impairing spermatogenesis (sperm production) and reducing testicular size.
Exogenous testosterone reduces the natural secretion of LH from the anterior pituitary glands, which reduces the body’s natural signal to the testicles to trigger testosterone and sperm production. Using HCG can help maintain that signal to the testicles, promoting natural testosterone and sperm production.
The use of HCG in combination with testosterone replacement therapy (TRT) provides a pathway to maintain intratesticular testosterone production necessary to maintain testicular function, volume, and spermatogenesis.
In clinical studies, eugonadal men (men with healthy gonadal glands and a normal testosterone value) who underwent TRT had a decline in their levels of intratesticular testosterone levels by 94 percent. However, men who received 250 IU SC every other day during TRT experienced intratesticular testosterone levels that dropped by only 7 percent. Other studies show that men who underwent TRT and received 500 IU of HCG every other day saw a 26 percent increase in intratesticular testosterone.
Men on testosterone therapy can use HCG to reduce the side effects of testosterone therapy. Common side effects of testosterone therapy include testicular atrophy and lowered sperm production. HCG may be considered by men who are considering testosterone therapy and want to preserve their fertility and/or the size of their testicles.
In men who present with infertility, likely as a result of testosterone therapy, recent studies show that HCG can stimulate the recovery of spermatogenesis (sperm production).
REGENX Health is different from other online clinics. We take pride in educating you – our patients – about the therapy you are undergoing. In our experience, the more you know about your health, the better results you’ll obtain.
Here’s what makes REGENX Health stand out:
Your healthcare is always expert. That’s because every virtual meeting you’ll have is with a boardcertified urologist who specializes in testosterone replacement therapy and men’s health. Other online men’s health clinics rely on mid-level health providers, nurse practitioners, or non-urologic physicians.
Your health and treatment are always physicianguided, in order to ensure your health and optimize your performance results. Each visit with a physician, scheduled every three months via video teleconference, provides a personable and convenient experience for our members, so we get to know you and you get to know us. (This timing is significantly more frequent than other providers.) Know that your therapy, management, and concerns will always be fully addressed.
Our pricing is always inclusive. Unlike other online men’s health clinics, there are no hidden fees or surprise prices. Your low, monthly investment includes everything you’ll need during your HCG therapy:
Online physician visits
Medications
Supplies
Delivery
Comprehensive lab work
As always, there are no long-term commitment requirements, so you can cancel anytime. All medication and supplies are mailed discreetly to your home or office. Unlike other providers, you’ll never have to visit a clinic weekly to get an injection. Instead, your labs are performed on your time at a location most convenient to you and you’ll handle your personalized treatment in your own time and privacy.
Your treating physician will determine the proper dosage regimen for your HCG therapy. Note that the total dosage and length of treatment may vary widely.
In the routine treatment of hypogonadotropic hypogonadism in adult and adolescent males, there are several common dosage regimens including but not limited to:
500 UI units IM or subcutaneous, 3 times per week
HCG 2,500 units subcutaneous 2 times per week in combination with FSH 150 IUs subcutaneous 3 times per week for a minimum of 6 months
HCG is supplied as a dry powder stored in a vacuum-sealed sterile vial. Before use, reconstitute the HCG powder with bacteriostatic water, which will also be provided during your treatment.
In your REGENX Health consultation, your physician will review proper mixing technique and correct amount of bacteriostatic water to mix with the HCG powder. For a two-vial package, directions are as follows:
Inspect the drug products for particular matter or discoloration.
Withdraw prescribed amount of bacteriostatic water from diluent vial and inject into lyophilized vial.
Agitate vial gently until powder is completely dissolved in solution.
Store dry power at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Once HCG is reconstituted with bacteriostatic water, store the HCG liquid in a refrigerator, between 36°F and 46°F (2-8°C).
Always store HCG and all medications out of reach from children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.
HCG is not right for everyone. Only your healthcare provider can decide if HCG is right for you.
Do not take HCG is you have or have had any of the following conditions:
Precocious puberty (an early puberty, typically defined as starting before age 9 in boys)
Prostatic carcinoma or other androgendependent neoplasm
Prior allergic reaction to HCG
Women and children under the age of 18 should not take HCG. Only those who have specifically been prescribed HCG should take it. Never share HCG with others, even if their symptoms are similar, as it may cause serious harm.
While no studies of HCG use in humans have been conducted, some herbal or alternative therapies may have effects on hypothalamic-pituitary functions or hormone concentrations, so they may interfere with HCG treatment.
The following suggests a few therapies that may interfere with HCG fertility treatment, though this list is not exhaustive:
Chaste berry (also known as chaste tree fruit or vitex agnuscasus)
Black cohosh (aka cimicifuga racemose)
Blue cohosh (aka caulophyllum thalictroides)
Always share a list of all medicines, herbs, supplements, and nonprescription drugs you use with your physician.
Uncommon side effects of HCG may include, but are not limited to, the following:
Metabolism and nutrition disorders. Water and sodium retention is occasionally seen after administration of high dosages; this is regarded as a result of excessive androgen production.
Reproductive system and breast disorders. HCG treatment may sporadically cause gynecomastia (male breast enlargement).