Question 1

What is Human Chorionic Gonadotropin (HCG)?

Accepted Answer

Human Chorionic Gonadotropin (HCG) is an analog of luteinizing hormone (LH). (An analog means it is identical at the molecular level.) Administering HCG to men can stimulate the testicles to produce testosterone. In men, the anterior pituitary gland produces LH in response to gonadotropic releasing hormone (GnRH) from the hypothalamus. LH acts on the Leydig cells of the testicles, stimulating the testicles to produce intratesticular testosterone and promote spermatogenesis (sperm production). The U.S. Food & Drug Administration (FDA) has approved the use of HCG in select cases of hypogonadism as a result of a pituitary deficiency (hypogonadotropic hypogonadism) in males. HCG may also be prescribed for off-label use.

Question 2

How does HCG support testosterone replacement therapy?

Accepted Answer

The use and administration of exogenous (external) testosterone in men can affect male fertility by impairing spermatogenesis (sperm production) and reducing testicular size. Exogenous testosterone reduces the natural secretion of LH from the anterior pituitary glands, which reduces the body’s natural signal to the testicles to trigger testosterone and sperm production. Using HCG can help maintain that signal to the testicles, promoting natural testosterone and sperm production. The use of HCG in combination with testosterone replacement therapy (TRT) provides a pathway to maintain intratesticular testosterone production necessary to maintain testicular function, volume, and spermatogenesis. In clinical studies, eugonadal men (men with healthy gonadal glands and a normal testosterone value) who underwent TRT had a decline in their levels of intratesticular testosterone levels by 94 percent. However, men who received 250 IU SC every other day during TRT experienced intratesticular testosterone levels that dropped by only 7 percent. Other studies show that men who underwent TRT and received 500 IU of HCG every other day saw a 26 percent increase in intratesticular testosterone.

Question 3

How is HCG used during testosterone replacement?

Accepted Answer

Men on testosterone therapy can use HCG to reduce the side effects of testosterone therapy. Common side effects of testosterone therapy include testicular atrophy and lowered sperm production. HCG may be considered by men who are considering testosterone therapy and want to preserve their fertility and/or the size of their testicles. In men who present with infertility, likely as a result of testosterone therapy, recent studies show that HCG can stimulate the recovery of spermatogenesis (sperm production).

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Disclaimer: The content on this website is not medical advice or a substitute for professional medical care, diagnosis or treatment. Your physician will determine if you are a candidate for therapy and advise how you should take the medication.

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