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Gettting started with Vardenafil (Levitra™️)
What is Vardenafil?
Vardenafil is the active ingredient in Levitra. Vardenafil is a prescribed drug that is used primarily to treat erectile dysfunction (ED), also known as impotence, which is the inability to get or maintain an erection satisfactory for intercourse.
Clinical studies have found Vardenafil to be highly effective for the treatment of ED in patients who have diabetes, hypertensions, and dyslipidemia (high cholesterol). Further studies revealed that men with low testosterone as well as ED respond well to Vardenafil in combination with a testosterone replacement regimen.
How does an erection occur?
The process of achieving an erection is complex. The first step is for a man to experience sexual arousal or an erotic stimulus. This arousal signals a cascade of events that relaxes cavernosal artery smooth muscles in the phallus. Parasympathetic nerves in the phallus release nitric oxide (N.O.), which increases cyclic GMP (cGMP), decreases intracellular calcium levels, and enhances smooth muscle relaxation. The relaxation of smooth muscle in the phallus allows for an influx of arterial blood, increased intracavernosal pressure, and erectile expansion and rigidity. Increased venous outflow, a passive process, maintains the phallus in an erect state.
When arousal has subsided, sympathetic nerves release norepinephrine, which stimulates alpha-adrenergic receptors. The resulting smooth muscle contraction causes the erection to reduce in size in rigidity.
How is phosphodiesterase (PDE) important for erectile function?
Nitric oxide and cGMP are essential components for smooth muscle relaxation in the phallus and vascular dilation. Without enough nitric oxide or cGMP, not enough blood can flow to the phallus for an erection.
Phosphodiesterase (PDE) enhances the breakdown of nitric oxide (N.O) and reduces the presence of cGMP. There are several types of PDE enzymes, but PDE-5 is the primary PDE enzyme in the male phallus. By preventing or inhibiting PDE-5, cGMP can maintain blood flow by increasing N.O. to the phallus, promoting an erection.
All oral ED medications, including Vardenafil (Levitra), are PDE-5 inhibitors.
What causes erectile dysfunction?
Erectile dysfunction is the inability to obtain or maintain an erection that is strong enough for sexual activity, including sexual intercourse. Approximately 52% of men older than 40 years old and 26% of men less than 40 years old have some degree of erectile dysfunction.
Many situations can interfere with a normal erectile function, including stress, depression, anxiety, low testosterone, smoking, physical inactivity, and the use of alcohol and/or drugs.
Other causes for ED can include an underlying cardiovascular condition or atherosclerosis. For example, obstructed or narrowed blood vessels can make it difficult for an erection to occur.
How does Vardenafil work?
The purpose of Vardenafil is to relax restricted or narrowed blood vessels and relax smooth muscles in the phallus in order for an erection to be achieved. Vardenafil specifically aims to address blood vessel-related erectile dysfunction by enhancing blood flow, relaxing cavernosal smooth muscle and increasing intracavernosal pressure resulting in a firm, rigid, and natural erection.
Vardenafil is one example of a type of drug known as a PDE-5 inhibitor (phosphodiesterase). PDE-5 inhibitors prevent the breakdown of nitric oxide, a potent vasodilator that is necessary to maintain a rigid and firm erection. Taking Vardenafil typically results in increased NO in the penile cavernosal tissue and muscles, which ensures a prolonged, stronger, more easily attained erection.
What is the difference between Vardenafil and Levitra?
Vardenafil is the active ingredient in Levitra. (There are several inactive ingredients, too.) Levitra is a brand name of the drug, whereas Vardenafil is the generic ingredient that can often be obtained in compound or at a more affordable price. Levitra is specifically marketed for the on-demand treatment of ED.
What is the best way to use Vardenafil for ED?
Swallow the medication whole or allow it to dissolve underneath your tongue, with or without food. Vardenafil takes effect quickly, as soon as 10 minutes of taking a dose, though more typically within 30 minutes. For maximum benefit, take your dose within 30-60 minutes of sexual activity. The effects of Vardenafil can last up to eight (8) hours, though in rare instances in may last for up to 12 hours.
How does Vardenafil differ from other ED medications?
There are four types of oral PDE-5 inhibitors that help treat ED and are currently approved by the U.S. Food and Drug Administration (FDA). These PDE-5 inhibitors work along the same pathway in the penis to promote smooth muscle relaxation and blood vessel dilation by increasing nitric oxide in the penis.
These drugs work in the same way, but differ in immediacy of action, half-life, side effect profile, and other characteristics. These slight differences may benefit some men and be ineffective for others.
Vardenafil (Levitra) was approved in 2003 for the U.S. market. It is known for its fast onset–Vardenafil can start working as quickly as 10 minutes after taking a dose. For maximum benefit, wait 30-60 minutes before sexual activity. Typically, Vardenafil stops working about eight (8) hours after taking a full dose, though its effects can last for up to 12 hours in some men.
The biggest different between Vardenafil and other PDE-5 inhibitors is that Vardenafil can increase QT prolongation, which can lead to irregular heartbeats. If you have prolonged QTc or are currently taking Class 1 or Class 3 antiarrhythmics, you may consider a different ED drug. Let your healthcare provider know about any cardiac history before starting any ED medication.
A doctor will assess your current health and your potential side effects when considering what type of ED medication is best for you. You may also have some input when choosing.
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Can I take Vardenafil for ED?
Yes. Vardenafil is used for the treatment of ED and should be taken one (1) hour prior to sexual activity for best results. For most patients, the starting dose is 10 milligrams (mg), up to once a day. Increase to 20 mg or decrease to 5 mg based on efficacy and tolerability.
Can I take Vardenafil for BPH?
No. Only Tadalafil (Cialis) has been approved for BPH.
Can I take Vardenafil if I have Liver problems?
In patients with moderate hepatic impairment (Child-Pugh B), the recommended starting dose of Vardenafil is 5 mg. The maximum dose in patients with moderate hepatic impairment should not exceed 10 mg.
How should I take Vardenafil?
Take Vardenafil exactly as prescribed by your physician or healthcare professional. A dose of 10 mg is standard, though your physician may increase dosage up to 20 mg or decrease as low as 2.5 mg based on your health and age, as well as your initial and longer-term tolerability and efficacy.
Do not take Vardenafil more than one (1) tablet in a 24-hour period. Do not break or split a Vardenafil tablet unless instructed by your health care provder; swallow it in its entirety, unless otherwise instructed by your healthcare provider. Do not use other ED medicines or treatments while taking Vardenafil.
Vardenafil is typically prescribed for use as needed. In this situation, you may take your prescribed dose of Vardenafil tablet within 10 minutes to eight (8) hours of sexual activity, though one (1) hour before sexual activity is ideal.
Never share Vardenafil with others, even if their symptoms are similar, as it may cause serious harm.
When is the best time to take Vardenafil before sex?
If you are taking Vardenafil on an as-needed basis, you may take one tablet before expected sexual activity. Generally, Vardenafil can help you have sex within 30 minutes and up to eight (8) hours after taking one dose.
Despite taking Vardenafil as prescribed, sexual stimulation is still necessary for an erection.
Can Vardenafil improve my sexual desire?
Vardenafil will not improve your desire for sexual activity or cure ED. A man’s sexual desire is only one of the many functions of testosterone. A low testosterone level can decrease a man’s desire for sexual activity. Vardenafil does not protect from sexually transmitted diseases (STDs), including HIV. Vardenafil is not a form of birth control for men.
Should I take Vardenafil with food?
You can take Vardenafil with or without food.
Can I take Vardenafil and drink alcohol?
Taking Vardenafil with alcohol is not recommended. Drinking too much alcohol can increase your odds of a headache, dizziness, elevated heart rate, or lower blood pressure.
The Centers for Disease Control and Prevention generally recommend no more than two (2) drinks per day for men. One drink is generally defined as 12 ounces of a regular beer (approximately 5% ABV), 5 ounces of wine, or 1.5 ounces of distilled spirits (such as vodka, whiskey, gin, tequila, etc.).