Vardenafil can cause a sudden drop in blood pressure. When combined with other specific medications, your blood pressure can drop to particularly unsafe levels, resulting in dizziness, fainting, and even a heart attack or stroke. Seek immediate medical help if this occurs. Other common side effects include: • Headache • Flushing • Indigestion or Dyspepsia (uncomfortable feeling in the uppermiddle part of your stomach) • Runny or stuffy nose • Sinusitis • Flulike symptoms • Nausea These side effects generally decrease over time, going away altogether within a few hours. You may also experience back or muscle aches within 12-24 hours of taking Vardenafil. These aches typically go away completely within two (2) days. Sexual activity can strain your heart, particularly if previous heart issues such as heart disease or a heart attack have already weakened your heart. If you experience chest pains, dizziness, or nausea during sexual activity, stop right away and seek professional medical help immediately.

Uncommon side effects of Vardenafil may include, but are not limited to, the following: • An erection lasting longer than four (4) hours. Known as priapism, an erection that won’t go away must be treated as soon as possible to avoid longterm damage, including the inability to have an erection. • Changes in color vision. You may see a blue hue or have difficulty differentiating between blue and green colors. • Sudden decrease in or loss of vision. In particularly rare instances, men taking Vardenafil or other ED medications may have a sudden decrease in or loss of vision in one or both eyes. If you experience a sudden vision decrease or loss, stop taking Vardenafil and seek immediate medical help. • Sudden decrease in or loss of hearing. Ringing in your ears and/or dizziness may accompany a sudden decrease in or loss of hearing, though it is rare. If you experience a sudden hearing decrease or loss, stop taking Vardenafil and seek immediate medical help.

Combining alcohol with Vardenafil may cause side effects, especially if you are drinking more than the recommended amount. Combining grapefruit or grapefruit juice with Vardenafil can result in unwanted side effects.

One dose of Vardenafil contains active ingredients that typically stay in your body for up to eight (8) hours. The effects of Vardenafil can last up to eight (8) hours, though in rare instances in may last for up to 12 hours. Other medications you may take, especially for kidney or liver health, can cause the active ingredients to linger longer than 12 hours.

Vardenafil is not right for everyone. Only your healthcare provider and you can decide if Vardenafil is right for you. Women and children under the age of 18 should not take Vardenafil. Only those who have specifically been prescribed Vardenafil should take it. Never share Vardenafil with others, even if their symptoms are similar, as it may cause serious harm.

If you experience serious side effects such as fainting, heart attack, loss of vision or hearing, or significant allergic reaction, seek immediate medical help. Contact your physician or professional health care provider if you have questions about Vardenafil.

Keep Vardenafil at room temperature, between 59°F and 85°F (15-30°C). Always store Vardenafil and all medications out of reach from children.

Do not take Vardenafil if you are currently taking other ED medicines or treatments, including Levitra. Do not take Vardenafil if you are currently taking any medications known as “nitrates”. Nitrates are often used to treat angina, a symptom of heart disease, that can result in pains in your jaw, chest, or arm. Ask your physician or healthcare provider if any of your other medications are nitrates. Nitrates may also be found in medicines including: • Isosorbide dinitrate • Isosorbide mononitrate • Recreational drugs known as “poppers”, which often contain nitrites called amyl nitrite or butyl nitrite Do not take Vardenafil if take any medication known as “guanylate cyclase stimulators”, which include Riociguat (Adempas), a drug that treats pulmonary hypertension and chronic-thromboembolic pulmonary hypertension. Other medications that can affect how you handle Vardenafil include: • Medicines known as “alpha blockers”, which can be prescribed for prostate problems and/or high blood pressure, among other issues. Combining alpha blockers with Vardenafil can result in dizziness or fainting. Alpha blockers may include, but are not limited to the following: • Cardura, aka doxazosin mesylate • Flomax, aka tamsulosin HCl • Hytrin, also known as (aka) terazosin HCl • Jalyn, aka dutasteride or tamsulosin HCl • Minipress, aka prazosin HCl • Rapaflo, aka silodosin • Uroxatral, aka alfuzosin HCl • Medicines that treat abnormal heartbeat, including: • Quinidine • Procainamide • Amiodarone • Sotalol • Antiretroviral drugs, including: • Ritonavir, aka Norvir • Indinavir sulfate, aka Crixivan • Satuinavir, aka Fortavase and Invirase • Atazanavir, aka Reyatax • Some types of antibiotics, including: • Biaxin, aka clarithromycin • Erythromycin, aka several brand names • Medicines known as “HIV protease inhibitors”, such as Norvir or Kaletra, aka ritonavir • Some types of antifungals, including: • Nizoral, aka ketoconazole • Sporanox, aka itraconazole

No. If you have had an allergic reaction to Levitra, do not take Vardenafil. Allergic reactions can include: • Hives • Rash • Swelling of your lips, throat, or tongue • Difficulty breathing or swallowing

Vardenafil is not right for everyone. Only your healthcare provider and you can decide if Vardenafil is right for you. Your physician or healthcare provider must know all medications and non-prescription drugs or medicines you are currently taking. Ask your healthcare provider if your heart is healthy enough for you to have sexual activity. You should not take Vardenafil if your healthcare provider has told you not to engage in sexual activity due to health problems. Before taking Vardenafil, tell your healthcare provider about all your medical problems, particularly if you have ever had: • Previous heart issues, such as irregular heartbeats, angina, heart failure, or heart attack • Low blood pressure • Rare heart condition known as long QT syndrome prolongation of the QT interval (this applies to family members as well) • High blood pressure that is not currently under control • Pulmonary hypertension • Stroke • Seizure • Liver problems • Kidney problems and/or required dialysis • Retinitis pigmentosa (a rare eye disease) • Severe vision loss, including a condition known as NAION • Stomach ulcers • Bleeding problems • Deformed penis shape and/or Peyronie’s disease • History of priapism (an erection that’s lasted for longer than four (4) hours) • Blood cell problems, such as multiple myeloma, sickle cell anemia, or leukemia • Hearing problems In the case of an emergency medical situation related to your heart, you must disclose the last time you took Vardenafil.

The U.S. Federal Aviation Authority approves the use of Vardenafil (Levitra) for the treatment of ED in its pilots. However, pilots may not use Vardenafil within eight (8) hours of pilot duties. The FAA also restricts the use of other ED medications for pilots.