Question 1

What is Ibutamoren Mesylate?

Accepted Answer

Ibutamoren mesylate, also known as MK-677, is a growth hormone secretagogue and an agonist of the ghrelin receptor. Ibutamoren Mesylate was developed as an oral acting, high affinity and long-lasting growth hormone (GH) secretagogue. Growth hormone secretagogues are a type medication that selectively stimulates natural growth home release and increases levels of IGF-1. Adult males with growth hormone deficiency who take Ibutamoren Mesylate will experience a sustained increase in the pulsatile release of human growth hormone and a subsequent rise in IGF-1 levels.

Question 2

What are the benefits of Ibutamoren Mesylate?

Accepted Answer

In men with growth hormone deficiency, the use of Ibutamoren Mesylate can significantly increase growth hormone levels. Increasing growth hormone levels can: Promote anabolism (protein synthesis) Reduce catabolism (the breakdown of protein and muscle tissue) Increase lean body mass Reduce fat mass Obtain more restful and deeper sleep Decrease low-density lipoprotein (bad cholesterol)

Question 3

How is Ibutamoren Mesylate used?

Accepted Answer

Ibutamoren Mesylate is an oral tablet that is ingested daily.

Question 4

How does Ibutamoren Mesylate increase Human Growth Hormone (hGH) levels?

Accepted Answer

Ibutamoren Mesylate (MK-677) provides a substantial and sustained increased release of Human Growth Hormone (hGH) in men with growth hormone deficiency.  MK-677 works by stimulating Ghrelin releasee.  Ghrelin was first identified and isolated in 1999. Ghrelin is a hormone that is released by the stomach and small intestine to increase appetite in states of hunger. Ghrelin also acts on the anterior pituitary axis to increase the pulsatile release of hGH. It is by this mechanism that MK-677 improves hGH release.

Question 5

How long does Ibutamoren Mesylate take to work?

Accepted Answer

In clinical studies, at a dose of 1mg/kg, growth hormone levels were found to increase 9-fold over an eight hours period, and IGF-1 levels were found to rise 30% at 8 hours after ingestion. Men taking Ibutamoren Mesylate may experience improvement in the signs and symptoms of growth hormone deficency before 3 months of therapy.

Question 6

What are the side effects of Ibutamoren Mesylate?

Accepted Answer

While growth hormone releasing peptides are generally safe, there is very limited data and the current studies are of small size to fully understand their side effect profile. From what studies have been performed to date, the most common side effect of Ibutamoren Mesylate reported has been a transient increase in appetite. The initial increase in appetite lasts for approximately 2-4 weeks and then subsides. Men with growth hormone deficiency often have a decrease in muscle mass and muscle wasting. The increase in appetite can improve lean muscle mass if a healthy diet rich in protein is utilized.  Other side effects include hyperglycemia, transient increases in cortisol prolactin, stomach ache, dizziness, lower extremity edema and transient increases in liver function tests (LFTs).

Question 7

Who should not take Ibutamoren Mesylate?

Accepted Answer

Ibutamoren Mesylate is for men with a diagnoses of growth hormone deficiency and as a treatment for wasting syndrome. Through existing studies there is support for the benefits of Ibutamoren to increase IGF-1 and Growth Hormone levels in men with growth hormone deficiency. Beneficial effects of Ibutamoren include improvement in muscle conditions, rise in testosterone levels, improvement in appetite, sleep and adiposity changes.   Long term use of Ibutamoren can increase the risk of hyperglycemia while other long term adverse effects are unknown given the lack of well performed and substantial studies. Any individual who has had an allergic reaction or contraindication to taking the medication should refrain from usage

Question 8

How is Ibutamoren Mesylate therapy monitored?

Accepted Answer

Men who have a chronic wasting condition and/or growth hormone deficiency and are undergoing therapy with Ibutamoren Mesylate are monitored through regular physical examinations for changes in body composition and measurement of IGF-1 levels. Other monitored parameters include but are not limited to Hemoglobin A1c, glucose, cortisol, and liver function tests.

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