17 Hydroxyprogesterone as a Biomarker for evaluating Intratesticular Testosterone.

Keywords: Clomid, HCG, Fertilty, Sperm Production, TRT, Testosterone Therapy Low-T

Testosterone in California, Organe County, Los Angeles, San Francisco, Texas, Austin, Dallas, Houston, El Paso, Galveston

Low-T, also known as hypogonadism, is medical condition defined as having a low testosterone level and symptoms of low sex drive, erectile dysfunction and low energy. Young men who often choose intramuscular testosterone cypionate or enanthate as treatment options for Low-T, may be unaware that testosterone can reduce a man’s sperm count. Testosterone replacement can be considered an infertility drug for men given its effect to lower sperm count to zero (azoospermia).

A study published recently in the Journal of Urology by Thiago et. al. evaluated the use of serum 17-Hydroxyprogesterone to monitor and assess intratesticular testosterone necessary for proper spermatogenesis (sperm production). Men on TRT will experience a decrease in intratesticular testosterone. Testosterone within the testicle is necessary for sperm production. Evaluating 17-Hydroxyprogesterone may provide insight and monitoring of fertility while a man is on TRT. For men who are using clomiphene citrate or human chorionic gonadotropin (HCG) either as monotherapy or with TRT, monitoring 17-Hydroxyprogesteron levels can be of clinical value to understand the intratesticular testosterone environment t