17 Hydroxyprogesterone as a Biomarker for evaluating Intratesticular Testosterone.
Keywords: Clomid, HCG, Fertilty, Sperm Production, TRT, Testosterone Therapy Low-T
Low-T, also known as hypogonadism, is medical condition defined as having a low testosterone level and symptoms of low sex drive, erectile dysfunction and low energy. Young men who often choose intramuscular testosterone cypionate or enanthate as treatment options for Low-T, may be unaware that testosterone can reduce a man’s sperm count. Testosterone replacement can be considered an infertility drug for men given its effect to lower sperm count to zero (azoospermia).
A study published recently in the Journal of Urology by Thiago et. al. evaluated the use of serum 17-Hydroxyprogesterone to monitor and assess intratesticular testosterone necessary for proper spermatogenesis (sperm production). Men on TRT will experience a decrease in intratesticular testosterone. Testosterone within the testicle is necessary for sperm production. Evaluating 17-Hydroxyprogesterone may provide insight and monitoring of fertility while a man is on TRT. For men who are using clomiphene citrate or human chorionic gonadotropin (HCG) either as monotherapy or with TRT, monitoring 17-Hydroxyprogesteron levels can be of clinical value to understand the intratesticular testosterone environment that is suitable for sperm production.
As detailed by the study, for young men who desire to be on TRT, measuring 17-Hydroprogestoenre can identify men who may have an underlying impaired sperm production anomaly.
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