Keywords: Testosterone and weight loss, Testosterone treatment for obesity, Lean Muscle Mass and TRT, Obesity and Low Testosterone, Estradiol, Aromatase, Fat cell, Lypolysis, Arimidex
It is well known that men with increased body fat have a low testosterone level. Testosterone levels decline as men age promoting weight gain. The decline in testosterone with aging correlates with an increase in truncal obesity (the accumulation of fat around the mid-section of the body) (See Tromoso Study & Quebec Family Study for more details). Studies have confirmed that losing weight can exponentially increase testosterone levels (Strain et. al. 1988). Furthermore, testosterone therapy can improve weight loss and reduce waist circumference in men.
There is a well-known cycle that exists in obese men with obesity driving testosterone levels lower, making it difficult to lose weight. This cycle is called the Hypogonadal- Obesity Cycle (Cohen 1999). The Hypogonadal - Obesity Cycle exists around the hypothesis that in fat cells exist an enzyme called aromatase. Aromatase converts testosterone to estradiol, the predominate form of estrogen in men. The greater and larger degree of fat cells in the body the higher activity of aromatase. Furthermore, obese men have a higher level of sex hormone binding globulin (SHBG) compared to men of normal weight. SHBG is a protein that binds testosterone in the bo