Testosterone Therapy and Losing Weight. A review of TRT dosages for weight loss.


Keywords: Testosterone and weight loss, Testosterone treatment for obesity, Lean Muscle Mass and TRT, Obesity and Low Testosterone, Estradiol, Aromatase, Fat cell, Lypolysis, Arimidex



It is well known that men with increased body fat have a low testosterone level. Testosterone levels decline as men age promoting weight gain. The decline in testosterone with aging correlates with an increase in truncal obesity (the accumulation of fat around the mid-section of the body) (See Tromoso Study & Quebec Family Study for more details). Studies have confirmed that losing weight can exponentially increase testosterone levels (Strain et. al. 1988). Furthermore, testosterone therapy can improve weight loss and reduce waist circumference in men.


There is a well-known cycle that exists in obese men with obesity driving testosterone levels lower, making it difficult to lose weight. This cycle is called the Hypogonadal- Obesity Cycle (Cohen 1999). The Hypogonadal - Obesity Cycle exists around the hypothesis that in fat cells exist an enzyme called aromatase. Aromatase converts testosterone to estradiol, the predominate form of estrogen in men. The greater and larger degree of fat cells in the body the higher activity of aromatase. Furthermore, obese men have a higher level of sex hormone binding globulin (SHBG) compared to men of normal weight. SHBG is a protein that binds testosterone in the body and prevents its activity with the androgen receptor.

As men gain weight, fat cells accumulate and are able to convert more testosterone into estradiol (predominate form of estrogen in men), promoting a low testosterone environment. Breaking this cycle can be achieved by testosterone replacement therapy, assisting in weight loss, improving metabolism, reducing fat cells and aromatase activity. Testosterone replacement therapy has been proven in several clinic studies to reduced waist circumference, improve insulin sensitivity increase lead body mass (muscle) and improve the symptoms of metabolic syndrome (hypertension, hyperlipidemia and obesity).


Clinical studies convey a testosterone therapy duration of 6-36 months can enhance weight loss and reduce waist circumference in men. Average testosterone replacement therapy dosages can range from 0.75cc to 1cc of 200mg/cc of testosterone cypionate weekly. Adding an estrogen blocker such as aromatase can assist in lowering elevated estrogen levels often present in obese and over weight men. Aromatase inhibitors such as Arimidex will also to raise testosterone, by preventing its breakdown. Testosterone replacement therapy (TRT) will also improve energy, glucose utilization and promote mental well being that aids in living a healthier lifestyle. Testosterone replacement therapy provide many benefits in obese and overweight men. Men who have low testosterone and desire to lose weight should consider having their testosteron levels checked and consider TRT if levels are low.

To learn more about Low-T, Weight Loss and Testosterone Therapy for physique enhancement, contact a professional at REGENXHealth.com today.

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Disclaimer: The content on this website is not medical advice or a substitute for professional medical care, diagnosis or treatment. Your physician will determine if you are a candidate for therapy and advise how you should take the medication.

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Low-T Therapy with testosterone in Texas