Sperm Function, Fertility and Testosterone

Keywords: Fertility, Sperm Function, sperm banking, infertility, Clomid, HCG, Anastrozole,


Many patients will ask “How long does it take after stopping testosterone replacement therapy for my fertility to return to normal?” The answer depends on several factors. First, how long has the patient been on testosterone replacement therapy (TRT). A longer duration of TRT, higher BMI and a higher dose of TRT can suppress sperm production more so than a shorter course or lower dosage of testosterone therapy. Second, is patient age. Men who are older and who are undergoing TRT can expect a longer sperm recovery time compared to a younger male. Third, during TRT the use of HCG can maintain spermatogenesis and testicular volume ( ie. prevent testicular shrinkage) . Using HCG in combination with testosterone can reduce the chance of infertility during TRT.

After a man starts testosterone replacement therapy, it takes approximately 2.7 months for the total sperm count to be reduced. After testosterone therapy cessation, it can often take 6 months before the total sperm count returns to normal. Spontaneous recovery of fertility is common after stopping testosterone therapy, yet this process can be expedited.

To expedite sperm recovery during or after testosterone therapy, men have several medication options that include:

· Selective Estrogen Receptor Modulators (SERMS) such as Clomid (Clomiphene Citrate)

· Aromatase inhibitors (Anastrozole)

o Effective with testosterone to estradiol ration less than 10

· Human Chorionic Gonadotropin (HCG)

· Follicular Stimulating Hormone (Recombinant FSH)

o Directly stimulates the pituitary gland to stimulate sperm production in the testis

o Very expensive

It is important to know that testosterone can be considered an infertility drug for men. Men who are trying to conceive with their partner or who may be looking to have a child in the near future, should consider testosterone replacement alternatives that increase testosterone and maintain sperm function. Many younger patients who desire testosterone commonly ask if sperm banking/preservation is a viable option to consider while obtaining testosterone therapy. While this approach may be expensive, let alone the price of in-vitro fertilization if the sperm were to be utilized, sperm banking is not necessary as fertility will commonly return to normal.


To learn more about Testosterone therapy and fertility or to increase your testosterone while maintaining fertility contact RegenxHealth today online.

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Disclaimer: The content on this website is not medical advice or a substitute for professional medical care, diagnosis or treatment. Your physician will determine if you are a candidate for therapy and advise how you should take the medication.

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