Will Testosterone Replacement Therapy (TRT) cause Hair Loss

Updated: Apr 25, 2020

Testosterone therapy causing male pattern baldness, androgenic alopecia

Keywords: Male Pattern Baldness, Androgenic Alopecia, TRT, Testosterone, Androgens and Hair Loss, Finasteride, Proscar, Dutasteride, Avodart, Propecia, Hair Transplant.

Will Testosterone replacement cause male pattern hair loss?

The most common regulator of human hair growth in men are androgens, principally testosterone. Androgenic alopecia, also known as male pattern baldness, affects approximately 80% of men. Male pattern baldness is characterized by a recession, thinning and loss of hair primarily from the temporal zones and vertex of the scalp. Men who have androgenic alopecia or male pattern baldness are genetically predisposed to hair loss, principally from the actions of Dihydrotestosterone (DHT). DHT is similar to testosteron, but it is much more potent androgen. DHT acts upon the bulb of the hair follicle to induce hair thinning and eventual hair loss. Unlike hair on the vertex and temporal zones of the scalp, hair located on the side the scalp are resistant to androgens.

DHT is an androgen that is derived from the breakdown of testosterone. Testosterone is broken down into DHT by an enzyme called 5-α (alpha)-reductase. For men who are genetically predisposed to have male pattern baldness the use of testosterone replacement therapy may accelerate the hair loss cycle by increasing the amount of circulating DHT