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Ibutamoren (MK-677): A Comprehensive Patient Guide on Use, Side Effects, Studies, and Dosage.

Explore Ibutamoren MK677: your complete guide to its usage, side effects, research data, and dosage. Empower your health decisions today.

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Ibutamoren, better known as MK-677, is a research drug that stimulates the production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) while maintaining normal cortisol levels [1]. Despite being commonly misclassified as a selective androgen receptor modulator (SARM), its accurate designation is a growth hormone secretagogue (GHS) and a ghrelin receptor agonist, which directly influence the release of growth hormones.

As an experimental drug, Ibutamoren has not yet received the green light from the Food and Drug Administration (FDA) for specific medicinal applications. Despite this, the drug has gained popularity in fitness and bodybuilding circles due to its potent anabolic effects, which can contribute to muscle growth, improved recovery rates, and fat loss.

In this comprehensive guide, we will delve into Ibutamoren's applications, potential side effects, relevant clinical studies, and recommended dosage. The aim is to provide an unbiased viewpoint that equips potential users with the information necessary to make informed decisions about its use.

What is Ibutamoren (MK-677)?

Ibutamoren (MK-677) was initially developed by Reverse Pharmacology and later by Merck Pharmaceuticals. It was designed to combat conditions such as muscle wasting, obesity, and osteoporosis [2]. As a potent, long-acting, orally active growth hormone secretagogue, MK-677 mimics the ghrelin hormone's role as the body's only known natural GH secretagogue [3].

MK-677 stimulates the release of GH from the pituitary gland, promoting the production of IGF-1 in the liver, thus potentially leading to anabolic effects in the body [4]. It does not affect cortisol levels, which sets it apart from other GH-stimulating compounds.

Clinical Studies

Although not yet approved by the FDA, several studies have been conducted on MK-677, revealing its potential benefits and side effects [5]. Here are some key studies:

Muscle Growth and Recovery

Muscle growth and recovery take a transformative leap with the introduction of MK-677. This drug has been demonstrated to significantly enhance muscle mass and increase metabolic rate without an accompanying change in body fat. This has been evidenced in a double-blind, randomized controlled trial conducted on healthy, obese men [6]. Importantly, these findings aren't stand-alone. Complementary research indicates that MK-677 boosts levels of growth hormone and insulin-like growth factor 1 (IGF-1), both of which are instrumental in improving body composition.

Specifically, these elevated hormone levels contribute to increased lean body mass while simultaneously having the potential to decrease visceral fat [7]. These studies cumulatively suggest MK-677's promising role in augmenting muscle growth and facilitating efficient recovery.

Bone Density

MK-677 isn't just about muscle growth and metabolism. Remarkably, a two-year study indicated that this potent compound could also increase bone mineral density in older adults [8]. This groundbreaking discovery opens up a new frontier for MK-677 and the potential treatment of osteoporosis. Imagine a future where this condition could be effectively handled or even prevented with the help of this compound. However, the scientific journey is all about rigorous scrutiny and validation. Therefore, while these preliminary results are indeed promising, more extensive research is essential to substantiate these findings and fully unlock the potential of MK-677 in osteoporosis treatment.

Sleep Quality

A study conducted on both younger and elderly adults found that MK-677 significantly improved sleep quality, particularly in the older group [9]. This high quality of sleep can lead to enhanced recovery and overall health. Delving further into the effects of MK-677 on sleep, it's noted that this compound additionally increases the duration of REM sleep, the stage of sleep typically associated with dreaming and memory consolidation [10].

This implies that users of this substance could potentially experience improved cognitive function and memory. It's important to acknowledge that sleep is vital for a variety of physical processes, such as tissue growth and repair, immune function, and metabolism regulation. Therefore, the benefits of increased sleep quality brought about by MK-677 extend far beyond simple rest, potentially impacting multiple dimensions of health and well-being.

Side Effects of Ibutamoren (MK-677)

Like all drugs, MK-677 can have side effects. Some of the most common include:

  • Increased Appetite: MK-677 is known to mimic the ghrelin hormone, which is often called the 'hunger hormone.' Therefore, increased appetite is a common side effect.

  • Fluid Retention and Edema: Some individuals using MK-677 have reported swelling in the lower limbs and hands due to fluid retention, a common side effect of increased GH levels.

  • Muscle and Joint Pain: Increased levels of growth hormone can sometimes cause muscle and joint pain.

  • Temporary Insulin Resistance: Some studies suggest that MK-677 might lead to temporary insulin resistance in some users. This could potentially elevate blood glucose levels, which could be concerning for individuals with diabetes or pre-diabetes.

  • Nausea and Bloating: These gastrointestinal side effects are typically mild and tend to decrease over time. However, if they persist, users should consider seeking medical advice.

  • Tiredness and Lethargy: Some users report feeling unusually tired and lacking energy, possibly due to changes in sleep patterns or quality.

  • Elevated Blood Pressure: There have been reports of elevated blood pressure in some individuals using MK-677.

  • Increased Prolactin Levels: There's a potential for a slight increase in prolactin levels. High prolactin levels can cause symptoms such as erectile dysfunction, breast tenderness and enlargement, and secretion of breast milk.


The dosage of MK-677 can vary depending on the individual's goals, health status, and tolerance. In clinical trials, doses ranging from 5mg to 25mg per day have been used. Many users report optimal effects at 20–25 mg per day, but it is always advisable to start off with a lower dosage and gradually increase according to individual response and tolerance.

Remember, as MK-677 can cause insulin resistance, it is crucial to monitor your blood glucose levels, especially if you have diabetes or are at risk.

Despite the potential benefits of MK-677, it is essential to keep in mind that the compound is still in the experimental phase. Therefore, its long-term effects are not fully known, and it is not yet approved for medical use by the FDA or other health authorities. Always consult with a healthcare professional before starting any new medication or supplement.


MK-677 is a promising compound that has shown potential benefits in increasing muscle mass, improving recovery, and enhancing bone density. It is distinctive in its ability to stimulate GH and IGF-1 production without affecting cortisol levels.

However, as it is still in the experimental phase, its use comes with uncertainty. Its long-term effects are poorly understood, and more research is needed to confirm its safety and efficacy. Furthermore, it is currently not approved by the FDA, and its use is mainly limited to research and off-label purposes.

Therefore, if you're considering using MK-677, it's crucial to consult with a healthcare professional. They can provide personalized advice based on your health status, goals, and risk factors. It is also necessary to obtain MK-677 from a reliable source to ensure its quality and purity.

At REGENX Health, we are committed to providing you with accurate, up-to-date information about cutting-edge health and wellness topics. We believe in empowering you to make informed decisions about your health.

Feel free to contact us to schedule a consultation with one of our healthcare professionals. We can guide you through your wellness journey, providing personalized advice based on the latest research and clinical evidence.


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