Maintaining energy levels while losing weight through diet and exercise can be tough. However, with these tips and tricks, you can keep your energy up and achieve your weight-loss goals without feeling sluggish or lethargic. Starting a weight-loss journey can be both exhilarating and intimidating, particularly when trying to find the perfect equilibrium between nutrition and physical activity. Maintaining high energy levels is not only vital for accomplishing daily tasks but also for keeping you motivated and invigorated as you progress towards your weight loss objectives. In this blog, we will delve into essential strategies for preserving your energy levels by optimizing your diet and exercise routines as you confidently stride towards a healthier, fitter you. By understanding the importance of a balanced diet, selecting the right type of exercise, and incorporating rest and recovery, you'll be better equipped to overcome challenges and enjoy a more energetic and fulfilling weight loss journey. Diet Strategies to Keep You Energized Diet is undeniably a critical component in maintaining energy levels as you work towards your weight loss objectives. Here, we’ll let you know the essential diet strategies designed to keep you energized and support your weight loss journey. By adhering to these recommendations, you'll be able to maintain high energy levels while efficiently shedding unwanted pounds. Prioritize Balanced Nutrition: A balanced diet that includes a variety of nutrient-dense foods from all food groups (vegetables, fruits, whole grains, lean proteins, and healthy fats) is crucial for sustained energy and effective weight loss. These nutrients fuel your body and ensure you have the principal resources to power through your day and workouts [1]. Opt for High-Quality Protein: Consuming adequate amounts of high-quality protein from sources such as lean meats, fish, legumes, and low-fat dairy products can help maintain and build lean muscle mass. This, in turn, supports your metabolism and provides you with sustained energy throughout the day. Choose Complex Carbohydrates: Opt for complex carbohydrates like whole grains, fruits, and vegetables over refined carbs like white bread and sugary snacks. Complex carbs provide a steady stream of energy and keep blood sugar levels stable, preventing energy crashes and cravings [2]. Stay Hydrated: Drinking plenty of water throughout the day is essential for maintaining energy levels and overall health. Dehydration can lead to fatigue, reduced mental clarity, and decreased physical performance. Aim to drink at least 8-10 glasses of water daily, and more if you engage in intense workouts or live in a hot climate. Space Out Your Meals: Eating smaller, more frequent meals throughout the day can help maintain stable blood sugar levels and halt energy dips. Aim for three balanced meals and two healthy snacks, spaced about three to four hours apart. Limit Processed Foods and Added Sugars: Processed foods and those high in added sugars can lead to blood sugar fluctuations and energy crashes. Reducing your intake of these foods and focusing on whole, natural ingredients can help stabilize your energy levels. Don't Skip Breakfast: Eating a nutritious breakfast sets the tone for the day and provides your body with the fuel it needs to start the day with energy. Skipping breakfast can lead to low energy levels and overeating later in the day. By implementing these key diet strategies, you can maintain high energy levels and support your weight loss goals, enabling you to lead a healthier, more vibrant life. Choosing the Right Type of Exercise, Intensity, and Recovery After discovering the appropriate diet strategies to keep your energy levels high, it's crucial to complement them with the right exercise strategies. A well-designed exercise routine not only helps you shed those extra pounds but also elevates your mood, enhances mental clarity, and contributes to your overall well-being. It's essential to understand the role of different types of exercises and their impact on your energy levels. A balanced routine incorporating aerobic exercises, strength training, and flexibility/balance exercises can help you avoid stagnation and unlock the full potential of your fitness regimen. For example, aerobic exercises improve cardiovascular health and increase stamina, empowering you to tackle daily tasks with gusto. In contrast, strength training exercises build lean muscle mass and maintain a healthy metabolism, ensuring your body burns calories efficiently, even at rest. Flexibility and balance exercises, like yoga or pilates, not only foster overall well-being but also prevent injuries and keep your body agile, allowing you to remain active and energetic throughout the day [3]. Optimizing your exercise routine requires considering factors like intensity, duration, and rest. Striking the perfect balance between high-intensity and low-intensity workouts, scheduling rest days, and incorporating active recovery activities will ensure your body has ample time to recuperate and replenish its energy reserves. By weaving these exercise strategies into your weight loss journey, you'll be well-equipped to maintain your energy levels, stay motivated, and achieve lasting success in pursuing a healthier, more vibrant lifestyle. Embrace the journey, and let your newfound energy propel you toward your goals! Lifestyle Factors to Keep You Energized Now that you've learned various diet and exercise strategies to maintain high energy levels, it's essential to remember that a successful weight loss journey goes beyond these two factors. It's also essential to address the key lifestyle factors that greatly impact your energy levels [4]. To ensure success on the bridleway to a healthier, more vibrant life, it's crucial to prioritize quality sleep, manage stress effectively, and stay consistent and patient with your efforts. Aiming for seven to nine hours of sleep each night, establishing a regular sleep schedule, and developing a calming bedtime routine will create a stalwart foundation for restful sleep [5]. Tackling chronic stress with techniques like deep breathing, meditation, journaling, or engaging in enjoyable hobbies helps maintain energy levels and supports weight loss goals. Lastly, focusing on consistency and patience, avoiding drastic changes or crash diets, and implementing sustainable habits will promote long-term success and give your body time to adapt to changes. Embracing these holistic approaches will help you maintain energy and thrive on your weight loss journey. Diet, exercise, and lifestyle choices all contribute to your ability to maintain high energy levels. Maintaining high energy levels during your weight loss journey requires a harmonious interplay between diet, exercise, and lifestyle factors. By embracing a well-balanced diet, selecting the most suitable forms of exercise, giving sleep the attention it deserves, and effectively managing stress, you can successfully lose weight while preserving your energy levels. Remember to be gentle with yourself and concentrate on formulating lasting habits that contribute to long-term success. Embark on this transformative journey confidently, knowing that every step you take brings you closer to improved health and well-being. Your dedication and perseverance will pay off as you experience the rewards of a healthier, more energetic lifestyle. Trust in the process and remind yourself that the journey is as sacrosanct as the destination, and your health and well-being are undoubtedly worth the effort. If you're prepared to revolutionize your weight loss journey while maintaining energy levels throughout the process, it's time to join REGENX HEALTH. Our comprehensive, holistic approach not only addresses diet and exercise but also tackles crucial lifestyle factors that contribute to lasting success. With CURVI, you'll receive personalized guidance, unwavering support, and an array of valuable resources orchestrated to help you attain a healthier, more vibrant life. Don't wait any longer; take the first step towards a happier, more energized you by signing up for CURVI today! Let’s embark on this transformative journey and craft a lifestyle that genuinely empowers and uplifts you. Experience the REGENX HEALTH difference and unlock the secrets to a sustainable and fulfilling weight loss journey. Your future self will thank you for it.

Summer is just around the corner, and many of us look forward to warm weather, sunny days, and fun outdoor activities. But for those struggling with excess weight, the thought of baring more skin in summer clothing or hitting the beach can be daunting. Fortunately, there’s a new FDA-approved medication that can help: Wegovy. Wegovy is a once-a-week injection that the FDA approved in June 2021. It can help adults who are obese or overweight and have at least one weight-related condition lose weight and keep it off. By acting like a hormone called glucagon-like peptide-1 (GLP-1), which controls hunger and food intake, Wegovy can make people feel less hungry and more full, and help them lose weight. In this blog post, we'll explore how Wegovy can help you get summer-ready by promoting weight loss and improving overall health. We'll also cover the benefits and possible side effects of Wegovy, as well as give you some tips on how to use it as part of a larger plan to lose weight. Whether you're out to shed a few pounds or achieve a major body transformation, read on to learn how Wegovy can help you achieve your summer body goals. Importance Of Weight Loss For Summer Weight loss is important for the summer for a number of reasons. First and foremost, it can have a positive impact on your health, improving blood sugar control and cholesterol levels and reducing the risk of obesity-related health conditions. By losing weight, you can also improve your physical appearance and increase your confidence and self-esteem, which can lead to a more definitive outlook on life. [1] Additionally, weight loss can help you participate in more summer activities and enjoy the season to the fullest. With increased energy levels and stamina, you'll be able to take advantage of opportunities to go swimming, hiking, biking, and more. Summer is also a time when many people are more self-conscious about their bodies and appearance, as they may be wearing less clothing and spending more time outdoors. Losing weight can help reduce discomfort and embarrassment related to excess weight, and make you feel more comfortable in your own skin. Moreover, summer is a time for fun and relaxation, and weight loss can help you feel more confident and happy, allowing you to fully enjoy the season. By taking steps to lose weight and improve your health, you can create a positive cycle of healthy habits that will help you maintain your weight loss and continue to enjoy a healthy lifestyle for years to come. What Is Wegovy? Wegovy is a medication that has been approved by the FDA for weight management in adults with obesity or overweight and at least one weight-related condition. It’s a brand name for semaglutide, a synthetic version of a hormone called glucagon-like peptide-1 (GLP-1) [2] that is manufactured naturally in the body. Wegovy is typically prescribed as a subcutaneous injection [3] given once a week. It should be used in combination with a reduced-calorie diet and heightened physical activity for optimal results. How Does Wegovy Work? Wegovy [4] works by mimicking the effects of GLP-1, which helps to reduce appetite and promote feelings of fullness. When injected once a week, Wegovy decelerates the movement of food through the stomach and increases feelings of fullness after eating. This leads to reduced food intake and, ultimately, weight loss. It is important to note that Wegovy isn’t a magic pill, and it should be used in combination with a reduced-calorie diet and increased physical activity for optimal results. Wegovy also helps regulate blood sugar levels and can improve cholesterol levels. This can help reduce the risk of obesity-related health conditions such as diabetes, heart disease, and stroke. The Benefits Of Wegovy Here are some benefits of Wegovy that make it a popular choice for individuals looking to achieve sustainable weight loss. Firstly, Wegovy promotes weight loss by reducing appetite and promoting feelings of fullness. In clinical trials, individuals who took Wegovy lost an average of 12–15% of their body weight over the course of a year, which is significantly more than traditional methods of weight loss [5]. By helping individuals achieve sustainable weight loss over time, Wegovy can improve overall health and well-being. Secondly, Wegovy has been shown to improve blood sugar control in individuals with diabetes or prediabetes. Reducing blood sugar levels abates the risk of complications related to diabetes, such as heart disease, kidney disease, and nerve damage [6]. Third, being overweight makes you more likely to get a number of health problems, such as heart disease, stroke, high blood pressure, and some types of cancer. Wegovy can reduce the risk of these and other health problems linked to obesity by encouraging people to lose weight. This can help people improve their overall health and well-being. Fourth, carrying extra weight can make it hard to do physical activities, which can make you feel tired and low on energy. Wegovy can help people lose weight and get more energy and stamina, which makes it easier to do things that require physical effort. Lastly, one of the challenges of weight loss is dealing with hunger and food cravings. Wegovy can suppress appetite and food cravings, making it less arduous to stick to a healthy diet and achieve weight loss goals. Side Effects of Wegovy And Precautions Like all medications, Wegovy may have potential side effects that individuals should be aware of. Some common side effects include nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, fatigue, and constipation. However, not everyone who uses Wegovy will experience these side effects. In rare cases, more serious side effects may occur, such as pancreatitis, gallbladder problems, or kidney problems [7]. These side effects are more likely to occur in individuals with a history of these conditions or other medical conditions. Wegovy For Summer-Ready Body Wegovy can be a useful tool for individuals looking to achieve a summer-ready body. By promoting weight loss, improving blood sugar control, reducing the risk of obesity-related health conditions, increasing energy levels, and reducing appetite and food cravings, Wegovy can help individuals achieve their weight loss goals and feel confident and vibrant. For those looking to achieve a summer-ready body with the help of Wegovy, there are many online weight loss programs that can provide guidance and support. REGENX Health is a cardinal example of an online weight loss program that utilizes cutting-edge therapies, including Wegovy, to help individuals achieve sustainable weight loss. The program is developed by board-certified physicians and provides a professional approach to weight management. As a member of REGENX Health, individuals will receive personalized weight loss plans tailored to their specific needs and goals. They will have unfettered access to a team of healthcare professionals, who can render guidance and support throughout their weight loss journey. In addition to the use of Wegovy, REGENX Health utilizes a comprehensive approach to weight loss that includes healthy eating habits, regular physical activity, and behavioral therapy or support groups. This approach is designed to help individuals develop sustainable lifestyle habits that promote long-term weight loss and overall health and well-being. REGENX Health also utilizes advanced technologies, such as remote monitoring and telemedicine, to make the weight loss program accessible and convenient for individuals. Members can track their progress and receive support from their healthcare team.

Discover Hollywood's obsession with Wegovy and Ozempic, the newest weight loss solutions, and the bittersweet reality behind them. Read on to learn about the history of weight loss drugs in Hollywood, the benefits and risks of using these medications, and the impact of celebrities on public perception. In a world where the image is everything and the camera doesn't lie, Hollywood has long been infatuated with the pursuit of physical perfection. From the iconic hourglass figures of the golden era to today's toned and chiseled physiques, the pressure to maintain an ideal body image can be as relentless as the paparazzi's flashbulbs. It's no surprise then that Hollywood celebrities are perpetually on the lookout for new and promising ways to shed pounds and stay in the spotlight. Enter Wegovy and Ozempic, the newest darlings of the weight loss medication scene. These FDA-approved drugs have quickly become the talk of the town, as celebrities and influencers alike are embracing them as their go-to solution for rapid weight loss. In this blog post, we'll delve into the world of Hollywood's latest weight loss obsession, exploring the potential benefits and pitfalls of this controversial trend. The Pressure On Hollywood Celebrities To Maintain A Perfect Image. In the entertainment industry, maintaining a perfect image is often seen as a necessary part of the job. From looking young and sporty to staying in shape, the Hollywood elite is under immense pressure to conform to unrealistic beauty standards. For many Hollywood stars, the pressure to maintain a flawless appearance can start at a very young age. Child actors and actresses are often cast based on their looks and are expected to maintain their image throughout their careers. This can lead to a preoccupation with physical appearance, as they are constantly evaluated and critiqued based on their looks. As they grow older and become more established in their careers, the pressure only intensifies, with many celebrities feeling like they are under constant surveillance. The pressure on Hollywood celebrities to retain a perfect image is not just harmful to them; it can also have a negative impact on society as a whole. It perpetuates unrealistic beauty standards and can lead to body shaming and other harmful behaviors. Unfortunately, the relentless pursuit of perfection can have egregious consequences for a celebrity's mental health. The media and public scrutiny can have a significant impact on celebrities' self-image and mental health. Many celebrities have spoken out about the pressure to look a certain way and the impact it has had on their lives. In some cases, this pressure can lead to disordered eating, body dysmorphia [1], and other mental health issues. One way that celebrities have tried to meet these beauty expectations is through the use of weight-loss drugs such as Wegovy and Ozempic. While these medications can be effective in promoting weight loss, they should only be used under the guidance of a healthcare professional and as part of a comprehensive weight management program [2] . It is important for society to recognize that beauty comes in all shapes and sizes and the entertainment industry ought to promote healthy body image and self-care practices, rather than perpetuate harmful beauty-related stigma [3]. The Need For A Balanced Approach To Weight Loss And Body Image Achieving ideal weight parameters is important for overall health and well-being, but it is also important to have a balanced approach to weight loss and body image. This means taking into account not only physical health but also emotional and mental health. The media and societal pressure can often create unrealistic beauty standards, leading to a negative body image and disordered eating patterns. This can have serious upshots for mental and physical health and even lead to the development of eating disorders. Therefore, it is important to adopt a balanced approach to weight loss and body image that takes into account individual differences and focuses on overall health and well-being. This might involve setting realistic goals for weight loss, focusing on healthy behaviors rather than a specific number on the scale, and recognizing and addressing negative thoughts and beliefs about body image. Wegovy And Ozempic As The Go-To Weight Loss Solutions Wegovy and Ozempic are both medications that have been approved by the FDA for weight management in adults with obesity or overweight and at least one weight-related condition. These medications work by mimicking the actions of a hormone called glucagon-like peptide-1 (GLP-1), which regulates appetite and food intake. By activating GLP-1 receptors in the brain, Wegovy and Ozempic can curtail hunger, increase feelings of fullness, and ultimately lead to weight loss. Wegovy was approved by the FDA in June 2021 for the treatment of obesity in adults who have a BMI of 30 or greater or who have a BMI of 27 or greater with at least one weight-related health condition such as hypertension or type 2 diabetes [4]. It is a once-weekly injectable medication that can be self-administered. In clinical trials, patients who took Wegovy shed an average of 15% of their body weight over 68 weeks [5]. Ozempic was approved by the FDA in December 2017 for the treatment of type 2 diabetes, but it has also been shown to promote weight loss [6]. It’s a once-weekly injectable medication that can be self-administered. In clinical trials, patients who took Ozempic lost an average of 8–10% of their body weight over 26–52 weeks [7]. For many who are tussling with obesity or are moderately overweight, these medications can be a life-changing answer to weight loss. In addition to promoting weight loss, they can also help improve other health markers such as blood sugar control, blood pressure, and cholesterol levels. While these medications can be effective in promoting weight loss, they may also have side effects that individuals should be aware of. Common side effects of these medications may include nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, fatigue, and constipation. However, not everyone who uses these medications will experience these side effects. Clients taking these medications should be closely monitored by a licensed healthcare professional who can monitor for potential side effects and tweak treatment as needed. A weight loss program that includes medications such as Wegovy or Ozempic should be comprehensive and personalized to meet the unique needs and objectives of each individual member of society. By incorporating nutrition counseling, physical activity, behavioral therapy, and medication management, individuals can achieve healthy and sustainable weight loss and improve their overall health and well-being. If you are interested in an online weight loss program that considers the use of medications like Wegovy or Ozempic, check out REGENX Health a digital platform developed by board-certified physicians to provide a professional approach to weight management utilizing cutting-edge therapies. Sign up as a member and commence your weight loss journey now!

CJC 1295: The research, indications, research dosage, and physiology explained. The benefits of growth hormone supplementation in adult-onset growth hormone deficiency. CJC 1295 clinic trials discussed Comparison of CJC 1295 to Sermorelin CJC 1295 is a very potent and long-acting growth hormone-releasing hormone (GHRH) analog. Let's break down exactly what that means and how CJC 1295 is an improved version of your natural GHRH. GHRH is a naturally occurring peptide made in the hypothalamus. The hypothalamus is a gland that sits at the base of the brain and regulates hormone release from the pituitary gland among other functions. When growth hormone is low in the body, GHRH is released from the hypothalamus and stimulates the somatotrophic cells located in the anterior pituitary gland to synthesize and release growth hormone (GH). GH provides the following physiologic and biological changes in the body: 1) adipogenesis ( fat regulation ) 2) improved sleep 3) maintenance of lean muscle mass 4) insulin regulation and 5) improved endurance. 6) increase in bone mineral density 7) improvement in quality of life questionnaires 8) increase in muscle strength 9) reduction in the risk of myocardial infarction 10) regulation of diastolic blood pressure In humans, GH is released via 8 -10 pulses over a 24-hour period. We a consider GH to be a pulsatile hormone, released in waves over time. The biological effects of GH on cells, tissues, muscles, and organs are principally mediated by IGF -1 and we measure IGF-1 in the body to determine GH levels and pulsatility. GHRH is a key contributor to the regulation of GH and IGF-1 levels in the body. HGH injections is a medication utilized to improve GH in human, but it is not natural. In the situation of a patient injection of exogenous GH, a patient's natural production will reduce because the body senses there is too much GH present. Exogenous HGH is only approved for a narrow subset of medication conditions, namely short stature in children to provide growth, Turner syndrome, Noonan syndrome, Prader-Willi syndrome, short stature homeobox-containing gene (SHOX) deficiency, and chronic renal insufficiency. In 2020 the FDA approved Sogroya® (somapacitan-beco) a human growth hormone analog indicated for the replacement of endogenous growth hormone in adults with growth hormone deficiency. CJC 1295 is a peptide that mimics the actions of GHRH. What makes CJC 1295 unique is its ability to increase your natural GH release in a pulsatile manner without reducing any negative feedback loops that would otherwise interfere with GH release. CJC 1295 has several benefits compared to native GHRH that include: i) CJC 1295 is longer acting than native GHRH. ii) CJC 1295 has a longer half-life than GHRH ( 8-10 days for CJC 1295 vs 10-12 min for iv GHRH). iii) CJC 1295 does not impair or affect the natural pulsatile release of GH. iv) CJC 1295 has a higher binding affinity to the GHRH receptor. The potency of CJC 1295, lends itself to the construction of the peptide by key substitutions at the 8,15,27, and 2 positions along the amino acid chain. Such substitutions provide a more stable CJC 1295 peptide thereby: i) reducing oxidative degradation ii) preventing proteolytic cleavage iii) prolonging the half-life of the peptide iv) enhancing bioavailability In addition, CJC 1295 is a much more potent and longer-acting GHRH analog compared to Sermorelin. Sermorelin is a commonly used peptide provided to treat patients with growth hormone deficiency when other alternative measures have failed and/or confirm a diagnosis of GH deficiency. Sermorelin has a half-life of 30 minutes while CJC-1295 has a half-life of more than a week. In preliminary studies, the safety, efficacy, and tolerability of injecting 125ug/kg of CJC 1295 were found to cause significant increases in GH and IGF levels in human subjects. Clinical studies by Treichman SL et. al. revealed A 60-ug/kg dose of CJC 1295 resulted in GH levels of 125% and IGF-I levels of 80%. In studies by Lonescu et.al on male subjects who received CJC 1295 no serious adverse effects were observed. The most observed effects were a change in heart rate that was dose-dependent and transient redness and tenderness at the injection site. No human subjects experienced any of the adverse effects commonly associated with exogenous human growth hormone therapy. A 2009 study by Lucila Sackmann Sala et al, studied the effects of CJC 1295 to increase growth hormone and IGF-1 levels in male subjects and identifying protein biomarkers in response to increased growth hormone levels. In the study, 11 healthy young male adults were administered a single dose of CJC 1295 via subcutaneous injection. The administered dose of CJC 1295 was 60-90 ug/kg. Serum was measured and analyzed one week before and after the injection. Within the serum, 192 spots ( a group of proteins) were measured and observed for post-translational modifications that would be detected on 2D gels. Of the 192 spots, only 97 spots were found to be present in all subjects. Of the 97 spots, 5 spots were found to display significant intensity differences between serum measured before and after subcutaneous injection of CJC 1295. Figure I and II adapted from Sackman et al. research paper represents a 3D modeling of the 5 spots before and after CJC 1295 injection. As you can see in the far left column demonstrating different protein changes revealed by topographic changes indicated by the arrow. The 5 spots were then further investigated for their identity using tandem mass spectrometry. The 5 spots (A-E) were identified as: A) Apoliprotein A1 (ApoA1), B) Albumin and Immunoglobin Fragment C) Transthyretin (TTR) D) Beta- Hemoglobin E) Albumin Fragment The proteonomic analysis of the 5 spots (proteins A-E) demonstrates the potential for using proteonomic changes as biomarkers to detect elevated levels of GH in male subjects for therapy monitoring or drug sport testing. In addition, the study conveyed that serum GH and IGF-1 levels increased one week after a single administration of CJC 1295, confirming previous trial findings. From clinical research trials to date, CJC -1295 is a GHRH analog that is more potent than native GHRH. CJC 1295 has been used in human subjects via clinical trials with documented safety and efficacy to raise GH levels. 1. Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009 Dec;19(6):471-7. doi: 10.1016/j.ghir.2009.03.001. Epub 2009 Apr 21. PMID: 19386527; PMCID: PMC2787983. 2. Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne J-P, Frohman LA 2006 Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analogue of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab 91:799–805 3. Díez JJ, Sangiao-Alvarellos S, Cordido F. Treatment with Growth Hormone for Adults with Growth Hormone Deficiency Syndrome: Benefits and Risks. Int J Mol Sci. 2018 Mar 17;19(3):893. doi: 10.3390/ijms19030893. PMID: 29562611; PMCID: PMC5877754.

Keywords: Nasal Testosterone Gel, Hematocrit, Hemoglobin, Androgel ™ What are the benefits of Testosterone Nasal Gel compared to other Testosterone therapies? Nasal Testosterone is a unique testosterone formulation compared to other forms of testosterone therapies. Nasal Testosterone gel restores serum testosterone levels to normal without effecting the hypothalamic pituitary axis. In comparison, most testosterone therapies such as intramuscular testosterone injections or topical testosterone creams will suppress the hypothalamic pituitary axis resulting in reduced sperm count and testicular atrophy. Nasal testosterone gel, is different, and preserves fertility 95% of the time in men while raising serum testosterone to therapeutic levels. How is Testosterone Nasal Gel different from Topical Testosterone Gel ( Androgel ™ ) ? Testosterone nasal gel is different from topical testosteroen gel such an Androgel ™ in the following ways: Testosterone nasal gel does not have a risk of transference to another person compared to Androgel ™. Testosterone nasal gel is applied to the inside of the nostril three times per day. Androgel ™ is applied only once per day the skin of shoulders or chest. Does Testosterone Nasal Gel increase hematocrit levels? Nasal testosterone gel does not cause a rise in hematocrit or hemoglobin levels often seen during TRT with intramuscular testosterone injections or topical testosterone cream. In a cross sectional study comparing polycythemia in men with Low T treated with testosterone cypionate injections vs testosterone nasal gel, the incidence of a rise in hematocrit was significantly lower in the group of men utilizing testosterone nasal gel compared intramuscular testosterone injections. How often do you apply Testosterone Nasal Gel? Testosterone Nasal Gel is applied 2-3 times per day to the inside of the nostril, along the mucosa border. How long does it take Testosterone Nasal Gel to work? Testosterone Nasal Gel is fast acting and can reach peak levels in the body in as little as 40 minutes after application. What are the common side effects of Testosterone Nasal Gel? · Elevated PSA · Headache · Rhinorrhea · Epistaxis · Nasal Discomfort · Nasopharyngitis · Bronchitis · Upper respiratory tract infection · Sinusitis · Nasal Scab Who is the ideal candidate for Testosterone Nasal Gel? An ideal candidate for Testosterone Nasal Gel is a male with low testosterone with signs and symptoms of Low T who desires testosterone therapy and preserve fertility. Nasal Testosterone Gel can also be utilized by men who do not desire to perform injections or are concerned about transference of topical testosterone creams. Do seasonal allergies affect the efficacy and absorption of Testosterone Nasal Gel? Seasonal allergies do not affect absorption or efficacy of Testosterone Nasal Gel to raise serum testosterone levels in men with low testosterone. For more information about all testosterone replacement therapies visit regenxhealth.com or contact us today.

What are the benefits of oral testosterone? 1) Convenience 2) Ease of Administration 3) Patient preference What are common ways testosterone replacement therapy is administered? Testosterone replacement therapy (TRT) can be administered in several different formulations and delivery mechanisms that include: 1) transdermal testosterone gel 2) intramuscular and subcutaneous testosterone injection 3) implanted testosterone pellets 4) dermal testosterone patches 5) Long-acting testosterone injection (every 10 weeks) 6) Intranasal testosterone gel 7) oral testosterone tablets Can Testosterone be taken by mouth? Yes. Oral Testosterone is a not new method to administer testosterone replacement therapy (TRT); rather, the mechanism by which oral testosterone is absorbed into the body has become more effective and advanced. New oral testosterone medications are able to bypass liver metabolism, without causing liver toxicity, an improvement from previous iterations of the drug. Oral Testosterone tablets are now able to sustain serum testosterone concentrations between 300 -1000 ng/dL. Is oral testosterone bad for you? New oral testosterone tablets are a now safe, convenient and effective method to raise serum testosterone levels in men with Low -T. Newer generations of oral testosterone pills that do not include the 17-alpha molecular configuration do not cause liver damage. First generation oral testosterone pills were synthesized with a 17-alpha structure attached to the testosterone molecular ring to prevent breakdown by the liver. This added structure stabilized testosterone during its ingestion, but was toxic to the liver. Enhancements and modifications to the oral testosterone pills delivery system, rather than changing the chemical structure of the testosterone ring, have allowed the medication to improve serum testosterone levels and prevent liver damage. Is Oral Testosterone effected by food intake? First generation oral testosterone tablets or pills require a fatty meal to assist in testosterone absorption. A fatty meal assists the testosterone pills absorption into the intestinal lymphatic system. Historically, first generation oral testosterone pills had difficulty raising serum testosterone levels sufficiently enough in the normal serum testosterone range and required multiple daily doses of the medication. New formulations of oral testosterone encapsulate a self- emulsifying drug delivery system that contains among other combinations, long chain fatty acids, enabling testosterone absorption into the lymphatic system without food, enhancing the medications efficacy and delivery. In conclusion, while earlier generation oral testosterone replacement required a fatty meal to assist in absorption, newer oral testosterone medications do not necessary require a fatty meal with medication usage. When is best time to take Oral Testosterone? Oral testosterone is often provided as an oral tablet or troche and recommended to be taken twice daily. Taking oral testosterone in the morning and before bed has been a commonly utilized regimen by patients. Which is better Oral Testosterone or Testosterone Injections? Intramuscular testosterone injections have been the gold standard for testosterone replacement therapy (TRT) since1935. Since then, newer methods of TRT have been introduced to market to provide men more convenient options to reach stable and elevated serum testosterone levels. Oral testosterone tablets are a way men can achieve elevated serum testosterone levels without the need for injections. Neither oral testosterone tablets or testosterone injections are necessary better rather it depends on a patient's preference, lifestyle, and desired expectations of testosterone therapy. How often do I take Oral Testosterone? Oral Testosterone is often split into twice daily dosing. Most men will take oral testosterone once in the morning and once at night. What does an Oral Testosterone troche taste like? Oral testosterone provided by our clinic has a marshmallow flavoring. Flavoring is important to enhance salivation which allows the medication to dissolve faster in the mouth. Does the Oral Testosterone Troche dissolve? An Oral testosterone troche is formulated to dissolve in the mouth. In contrast an oral testosterone tablet is designed to be swallowed. Can I drink alcohol with Oral Testosterone? It is recommended that alcohol not be consumed during use with an oral testosterone pill or troche. Can Oral Testosterone be detected in Urine? Yes. Testosterone Undecanoate can be detected in plasma and urine. Detection of oral testosterone can be detected in blood plasma and urine as soon as 1 to 1.5 hours after ingestion. What labs should be monitored while taking Oral Testosterone Tablets? Liver Function Test Lipid Panel Total Testosterone Basic Metabolic Panel Hemoglobin and Hematocrit Lipid Panel Estradiol

Keywords: Covid 19, Low T, Low Testosterone Risk factor for Covid 19. COVID-19 is a novel respiratory virus that has been to have shown to affect men more than women. Men who contract the COVID-19 virus have worse clinical outcomes compared to women. More men have been admitted the hospital for Covid 19 symptoms compared to women. A possible etiology that has been investigated for this gender difference in COVID-19 health outcomes are sex hormones, specifically testosterone and its immunologic protection it may impart against Covid 19 outcomes. Men who have Low Testosterone (Low T) and who contract the Covid 19 virus are found to have 1) worse clinical outcomes 2) higher risk of death 3) higher rate of ICU admission 4) higher risk of intubation in the ICU and 5) longer hospital stays. Androgens and their role in the COVID -19 disease process is spurring more research to illicit any protective mechanism that testosterone replacement therapy (TRT) may provide in preventing severe Covid 19 symptoms. Much of the current research suggest that a low serum testosterone level increases the risk of developing severe COVID- 19 symptoms. In several studies, men with Low Testosterone (Low -T), and who contracted COVID-19, were more likely to be admitted to the ICU and have increased mortality (death) from the virus. Low T was found to be present in approximately 90% of patients admitted to the hospital for Covid-19. Testosterone plays an integral part in modulating the human immune system. Men who have Low T exhibit a pro-inflammatory state characterized by a higher level of inflammatory markers that include C reactive protein, IL-1, IL-2 and TNF – Alpha. The COVID 19 virus damages tissues in the body by causing an extreme release of these inflammatory markers, called a cytokine storm resulting in tissue, vessel and lung damage. Elevated levels of testosterone suppress cytokine activity and production which may protect the body from a cytokine storm. In addition, studies have shown that testosterone replacement therapy (TRT) may suppress a pro-inflammatory state. Androgen receptors are prevalent on white blood cells, promulgating the theory that testosterone acts as a signal to modulate the immune system. IL-6 is a pro inflammatory biomarker that is elevated in patients who contract COVID-19. Testosterone down regulates IL-6 expression and protects against immune modulated diseases. Patients who have preexisting low serum testosterone level (Low T) have higher than normal IL-6 level and often have more severe COVID-19 symptoms and adverse health outcomes. More research is needed to further illicit the exact role testosterone replacement therapy (TRT) may have to benefit males who contract COVID-19 and prevent severe health outcomes.

Keywords: Testosterone Cypionate, Testosterone Enanthate, Testosterone Dose, Testosterone Injection Amount, Testosterone and Athletic Performance. TRT, Low T. When providing testosterone replacement therapy (TRT) to men, a clinician should consider the following : 1) Patient expectations of Testosterone Replacement Therapy 2) Desire for fertility 3) Patient’s body mass index 4) Lifestyle and Nutritional habits 5) Exercise Routine 6) Plan duration of TRT 8) Estrogen Mangement 9) Comfortability with sterile injection technique 10) Patient reliability to follow for scheduled labs and open communication. When deciding on the right testosterone dosage for a patient, the majority of guidelines recommend to supply a testosterone dosage necessary to keep serum testosterone levels within the range of 400-600 ng/dL. Most physicians would consider an optimal testosterone dosage of 1cc of testosterone cypionate or testosterone enanthate, 200 milligrams per ml, every 14 days. More experienced clinicians are comfortable with treating patients with 200mg/cc of Testosterone Cypionate weekly or twice weekly. The half of testosterone cypionate is eight days. It is our opinion that testosterone should be provided every 7 days to maintain elevated and sustained therapeutic serum testosterone levels. For patients who are comfortable with injecting testosterone, increasing the frequency of testosterone injections to twice weekly can 1) maintain steady state testosterone levels 2) reduce side effects 3) prevent large surges in hemoglobin and hematocrit values to men who are undergoing monthly phlebotomy and 5) reduce large fluctuating (peaks and throughs) serum testosterone levels. Larger men, men who are more obese, often require a larger dosage of testosterone replacement to obtain therapeutic serum testosterone levels. Larger men, have a larger volume of circulating blood in the body, and exogenous testosterone can be diluted in such a large volume of blood. Men of larger body weight or muscle mass ( ie: strength athletes and bodybuilders) often require a higher testosterone dosage adjustment. Furthermore, heavier men have more adipose tissue resulting in more aromatase activity unlike athletes who have lower adipose content. Testosterone is converted into estradiol ( primary form of estrogen in men) by aromatase. The aromatase enzyme is present in adipose tissue ( fat cells). Heavier men often have higher aromatase activity and higher estradiol levels, imparting a low testosterone environment. Consideration for the in addition of an aromatase inhibitor, such as Anastrozole, is needed in obese males to combat the obesity-Low Testosterone cycle. For more one Estrogen management in males click here. Bodybuilding athletes have been reported to use 400mg -1000mg of Testosterone Cypionate per week and sometimes higher dosages accompanied by other anabolic steroids during cycling periods. In a study of athletic performance published in the New England Journal of Medicine, a dose of 600mg of testosterone enanthate in sesame oil injected intramuscular for 10 weeks combined with strength training has been shown to increase fat free mass and muscle hypertrophy. Studies have also provided evidence that Testosterone replacement can reduce waist circumference by 10% and may be a viable addition treatment for the treatment of obesity. Long term and super physiologic doses of testosterone can have several deleterious effects to the body including but not limited to 1) Emotional lability 2) Testicular atrophy 3) Fluid Retention 4) Gynecomastia 5) Fatigue 6) Anger 7) Depression 8) Cholesterol abnormalities and 9) Cardiovascular abnormalities. Newer methods of administering testosterone via the subcutaneous injection route have become more popular. Research has elicited similar pharmacokinetics of subcutaneous delivered testosterone when compared to intramuscular testosterone injections. Subcutaneous testosterone injections are injections given in the abdominal fat pad near the umbilicus (belly button). The injections are given with a very fine and short insulin tip needle. The benefits of subcutaneous testosterone injections include, among others: 1) less discomfort at the injection site 2) smaller needle size for the needle phobic patient 3) better visibility of the injection site compared to the buttock region. For more information on testosterone replacement therapy please visit www.RegenxHealth.com

Benefits of Subcutaneous testosterone injection vs Intramuscular Testosterone Injection. Testosterone has commonly been administered as an intramuscular (IM) injection since the 1930’s. While many testosterone products have been introduced into the market place to make the administration of testosterone more user friendly, such as testosterone gels, trans nasal testosterone, transdermal testosterone preparations, oral testosterone tablets, testosterone pellets and long-acting testosterone esters, intramuscular testosterone injections have been the most potent, proven, reliable and most cost effective way to to replace testosterone. Another route of testosterone injection into the subcutaneous (Subq) fat has proven to achieve steady state and therapeutic stable serum testosterone levels in male patients similar to intramuscular testosterone injections. Subcutaneous testosterone injections offer the following benefits: 1) Ease of administration and less discomfort 2) Well tolerated 3) Minimal testosterone peak and trough fluctuations 4) Less chance of venipuncture How to inject Subcutaneous (SubQ) Testosterone Testosterone cypionate and Testosterone enanthate are thick viscous solutions. The needle used to draw up and inject intramuscular testosterone is often a 22-23 gauge needle. When injecting testosterone into the subcutaneous fat under the skin, the same same needle is used to draw up testosterone but a different much finer, thinner and shorter needle is used for the injection . A 18-to-22-gauge needle is used to draw the testosterone solution into a 1cc syringe to the desired amount. The needle is removed and replaced with a fine 25- or 27-gauge 5/8-inch needle. Commonly used sites for Subq injection of testosterone include the abdominal fat or the thigh. Sterile technique and all injection precautions utilized with IM injections are identical to the subcutaneous testosterone injection technique. Always clean, with an alcohol prep pad, the top the testosterone vial and the skin prior to puncture and injection of testosterone. Which one is better, Grapeseed Vs. Cottonseed oil for SubQ Testosterone injection? Testosterone is dissolved in an oil commonly grapeseed or cottonseed oil. Grapeseed oil often has a lower viscosity and is much easier to inject through a fine injection needle compared to cottonseed oil. For this reason, testosterone in grapeseed oil is the optimal solution to inject testosterone via the subcutaneous route. How often do I need to inject Testosterone SubQ? Subcutaneous testosterone can be injected biweekly or weekly similar to the IM route of testosterone injection. While some clinics may have advise patients to inject a low dose of testosterone daily, the majority of studies investigated the efficacy of subcutaneous testosterone injection weekly or biweekly. For more information on Testosterone therapy visit us at REGENX Health.

Men commonly ask the following questions when they inquire about testosterone therapy: 1) What should my testosterone level be for my age? 2) Is my testosterone level too low for my age? 3) How high should we aim to get my serum testosterone level on testosterone therapy? There is no defined level of serum testosterone for a man by age. Rather, we utilize a reference range of testosterone levels from 250-950ng/dL as being within normal. There are many variables that can account for a man’s serum testosterone level that include age, genetics, muscle mass, fat mass, diet, exercise routine and co morbidities. Therefore, when a man asks “what is a normal testosterone level” the answer is between 250-950ng/dL. When measuring your serum testosterone, a testosterone level measured in man to be below 150ng/dL should have an addition workup. A testosterone level below 150mg/dL needs be investigated to rule out other pathologies emanating from the pituitary gland. A level less than 150ng/dL is considered to be too low for a man. Some men, may experience symptoms of Low-T that include lack of energy, decreased muscle mass, loss of sex drive, erectile dysfunction, decreased stamina, weight gain, impaired concentration and fatigue even when their testosterone level may fall within the normal reference range. Is it ok to treat a man with testosterone therapy even if their serum testosterone is within the normal reference range? The answer is yes, provided that no other factors are responsible or contributing to the patient’s symptoms. There exists genetic variability in the androgen receptor and its effect on the human body that varies between men. Some men may have no symptoms of Low-T while other men do not, even when their serum testosterone levels are the same. This can be accounted for by genetic component of the androgen receptor and how men respond to Low T thearpy. We aim to keep a patients serum testosterone level in the high normal or supra-physiological range while monitoring labs every 3-6 months. Factors that can limit a men’s testosterone from being in the high supra-physiological range include medication side effects on the body, elevation in hemoglobin and hematocrit, rise in prostate specific antigen among other laboratory values.

Over 60 years ago, studies by Huggins et. al. revealed that lowering testosterone levels (medical castration) can cause suppression and regression of prostate cancer. From this study, Urologists and physicians have been cautious to prescribe testosterone therapy in men who have been treated for prostate cancer for fear of prostate cancer progression and/or recurrence. The dictum that many physicians practiced was lowering testosterone levels causes prostate cancer regression; then the opposite may be true, testosterone supplementation can cause prostate cancer to emerge. Since Huggins initial paper in 1941, more research and clinical trials on TRT and prostate cancer have been performed. The findings revealed: Testosterone replacement therapy (TRT) in men with history of prostate cancer is safe. TRT does not increase the risk of recurrence or progression of prostate cancer in men who are on active surveillance or have undergone a radical retropubic prostatectomy or radiation therapy. Prostate Specific Antigen (PSA) is the primary screening tool used for prostate cancer. In men who undergo intramuscular injections of testosterone a slight rise in PSA is expected. This slight rise in PSA is not an indication of prostate cancer, but rather a representation of the effects of androgens on benign prostatic growth. PSA should stabilize to a new constant once steady state testosterone levels are achieved. In a male patient planning to undergo TRT, obtaining a baseline PSA and ruling out risk factors for prostate cancer is recommended. To learn more and obtain professional testosterone replacement therapy visit with an expert at REGENX Health.

Keywords: Total Testosterone, Free Testosterone, Lipid Panel, PSA, Hemoglobin, Hematocrit, Complete Metabolic Panel, Estradiol, Estrogen in Men. Testosterone Testosterone is most accurately measured in the morning, more specially before 11:00am. Testosterone is highest in morning and then declines throughout the day. Measuring serum testosterone in the morning allows a physician to observe your highest peak serum testosterone value. Serum testosterone declines throughout the day unless you engage in physical activities that will raise serum testosterone levels. A total testosterone value less than 300ng/dL is considered a reasonable cut off for men to be diagnosed with having Low-T. When reviewing your lab form, different lab companies have different intervals for what is considered a normal testosterone value. Both Quest® and LabCorp® have different values for the normal range of testosterone for men. Often men who are in the lower quantile of the testosterone values are good candidates for testosterone replacement therapy (TRT). Once a testosterone value less than 300ng/dL is measured a physician should also assess the patient’s symptoms. The clinical diagnosis of Low-T is a combination of both a testosterone value less than 300ng/dL and symptoms of Low-T. On occasion a patient may have a testosterone value of 400ng/dL and may still exhibit symptoms of Low-T. Providing a patient with testosterone replacement therapy despite not having a testosterone value measured to be less than 300nd/dL is per the physician’s judgement and understanding the risk and benefits of testosterone replacement therapy (TRT). Free Testosterone Free Testosterone measurement is not considered a standard test initially obtained on men who are being evaluated or Low-T. Free Testosterone is the biological active portion of the total testosterone that is able to exert an effect on the androgen receptor. Total Testosterone = Free testosterone + Bound Testosterone. A physician may desire to order a free testosterone level if a man’s total testosterone is normal yet symptoms of Low-T are present. Free testosterone provides a physician a better understanding of your total testosterone breakdown. For more information on measuring free testosterone and factors that can affect free testosterone visit the following article. Lipid Panel A lipid panel is a blood test that measures your cholesterol and triglycerides (fats in the blood). A lipid panel will often report the following measures: Total Cholesterol Triglycerides High Density Lipoprotein (HDL) Low-Density Lipoprotein (LDL) It is important for a physician to asses a lipid profile when treating a patient on testosterone, because testosterone replacement therapy can alter lipid parameters. Total Cholesterol: an evaluation of all cholesterol levels in the blood (combines your HDL, LDL etc.). A normal Total Cholesterol level is less than 170mg/dL Triglycerides: a type of fat found in your blood. The body converts the calories you ingest into triglyceride’s to be used as energy when needed. Triglycerides are a type of stored energy. Elevated triglycerides can accumulate in major blood vessels, hardening and thickening the walls of major arteries in the body. This can lead to stroke, heart attacks and elevated blood pressure (hypertension). Normal Triglyceride levels are less than 150mg/dL. High Density Lipoprotein (HDL): a good type of cholesterol in your body that prevents and protects arteries and your heart. Higher is better. A value of 45mg/dL for HDL is good. Low Density Lipoprotein (LDL): A bad type of cholesterol that builds up in arteries and can contribute to heart disease, high blood pressure and stroke risk. A good value for LDL is less than 100mgdL. Hemoglobin and Hematocrit Hemoglobin and Hematocrit are measurements of the total number of red blood cells and volume of red blood cells respectively. TRT can raise red blood cell volume in the body by stimulating the bodies bone marrow to produce more red blood cells. In fact, testosterone used to be a treatment for patients with anemia (low red blood cell count . Higher levels of blood volume and red blood cells can thicken the blood. This can lead to side effects of TRT. Monitoring hemoglobin and hematocrit is imperative to proper Low-T therapy and reducing side effects. Luteinizing Hormone (LH) LH is a hormone produced by the anterior pituitary gland and stimulates the primary production of testosterone from the testicles. Measurement of LH provides insight into whether a man’s low testosterone is due from testicular failure or from pituitary dysfunction. Sex hormone Binding Globulin (SHBG) Sex hormone binding globulin (SHBG) is a protein made by the liver and binds testosterone in the body. Testosterone bound to SHBG prevent testosterone from binding to the androgen receptor. Men with elevated SHBG levels can exhibit an elevated total testosterone level but still have a significant portion of their serum testosterone bound to SHBG, lending to symptoms of Low-T. Measuring SHBG helps a clinician better understand total testosterone value and tailor therapy to improve TRT response. Complete Metabolic Panel (CMP) A complete metabolic panel (CMP) is blood measurement of the is comprise of liver functional panel and basic electrolytes to asses potassium, renal function and sodium among others. A CMP can given insight into underlying medical conditions prior to starting TRT. Estradiol The predominate form of estrogen in men is called Estradiol (E2). Estradiol is a breakdown product of testosterone. Measuring estrogen levels in men before TRT is important to assess the degree to which a man breaks down ( aromatizes ) testosterone. Arimidex is an estrogen blocker medication is that is commonly prescribed with testosterone to keep exogenous testosterone from being broken down and maintain healthy estrogen levels. Estrogen levels are important for healthy male sex drive, erectile function and vascular health. The goal if estrogen management is to maintain estrogen in healthy range while on TRT and not to keep is consistently low. Learn more how to manage estrogen in men. To obtain TRT from an physician at REGENX Health, Contact Us today