Keywords: Testosterone Pellets, Testosterone Gel, Testosterone Injections, Testosterone Patches, Testosterone Pellets, Testosterone Cypionate, Testosterone Enanthate, Testosterone Undecanoate, Oral Testosterone, Buccal Testosterone, There are a number of low-testosterone treatments that can be integrated into a man's regular routine. Based on your goals, lifestyle, and conversation with a Regenx Health provider, you can find the one that works for you. Here’s a primer to consider your options for testosterone replacement therapy before a consultation at REGENX Health. 1. Intramuscular Injection Pros: One intramuscular injection that lasts all week. The most potent form of testosterone replacement therapy compared to other formulations. Experienced testosterone users and physique athletes often inject testosterone twice a week. This can help improve steady state levels and reduce significant peaks and valleys experienced with once a week injection of high testosterone dosages. Cons: Some therapy centers require you to come in for your shot every week. That can be a hassle and time consuming .At REGENX Health, we teach our patients how to manage the injections at home. Gaining comfort with testosterone injections for new patients can take time, but our physicians can teach you an easy and painless technique to enhance results. Read more how to reduce injection site discomfort. 2. Transdermal Gels Pros: One application every morning mimics the natural release of testosterone in the body. The gel dries quickly with little residue, and it’s easy to apply. Benefits of transdermal gels include more steady state levels of testosterone. Cons: Skin contact with others within two hours is discouraged since the gel can transfer to other individuals. Some find a daily application to be another thing to have to do. 3. Transdermal Patches Pros: Limits the need to apply a gel every day. Cons: Could cause a skin irritation. The patch must be applied to a hairless area near or on the scrotum, and some find the grooming cumbersome. The scrotum provides the best surface for testosterone to be absorbed, yet the patches have gone out of favor since newer testosterone mediums and formulations have entered the market. 4. Oral Testosterone Pros: No shots or skin treatments. The tablets are easy to swallow. Cons: Poor bioavailability and short term of action. What this means is that it is degraded by the body quickly and so you have to take several pills, often 4, throughout the day in order to see results and maintain serum testosterone-levels. There is also a higher risk of liver toxicity associated with oral intake of testosterone compared to other formulation. While newer oral testosterone pills have improved the side effect profiles, the significant amount of pills that must be taken throughout the day have made them an unappealing testosterone replacement option for men. 5. Buccal Testosterone Pros: This tablet adheres to the inner lining of the gum (similar to dip tobacco). The testosterone medication is absorbed across the mucous membrane of the inner cheek. It has to be applied twice daily. So there is no shot, no skin application, and fewer treatments than oral pills. Cons: The main side effect of the medication is gum irritation. There are also problems as the tablet may get dislodge from the gum and have to be reapplied. Eating food, tooth brushing, alcohol intake and chewing gum can interfere with the medication absorption. 6. Testosterone Pellets Pros: Pellets are placed under the skin and have the longest duration of all the testosterone replacement methods, lasting 4-6 months. Cons: In-office procedure, repeated min. 2x per year. Pellets, if not place correctly can extrude from the skin and incision site infection can occur. Scaring of the skin wear the implants are placed is inevitable and not desired. The right choice of testosterone delivery is truly based on a patients preference and lifestyle. Some men respond better to certain types of testosterone delivery. The most common and favorited delivery option by far is testosterone injection provided the high levels of serum testosterone that can be produced. By working with a physician, the right treatment is found not only in results, but in what works for your lifestyle. To gain more insight into the right testosterone replacement therapy formulation, contact a Regenx health provider.

Keywords: Testosterone and weight loss, Testosterone treatment for obesity, Lean Muscle Mass and TRT, Obesity and Low Testosterone, Estradiol, Aromatase, Fat cell, Lypolysis, Arimidex It is well known that men with increased body fat have a low testosterone level. Testosterone levels decline as men age promoting weight gain. The decline in testosterone with aging correlates with an increase in truncal obesity (the accumulation of fat around the mid-section of the body) (See Tromoso Study & Quebec Family Study for more details). Studies have confirmed that losing weight can exponentially increase testosterone levels (Strain et. al. 1988). Furthermore, testosterone therapy can improve weight loss and reduce waist circumference in men. There is a well-known cycle that exists in obese men with obesity driving testosterone levels lower, making it difficult to lose weight. This cycle is called the Hypogonadal- Obesity Cycle (Cohen 1999). The Hypogonadal - Obesity Cycle exists around the hypothesis that in fat cells exist an enzyme called aromatase. Aromatase converts testosterone to estradiol, the predominate form of estrogen in men. The greater and larger degree of fat cells in the body the higher activity of aromatase. Furthermore, obese men have a higher level of sex hormone binding globulin (SHBG) compared to men of normal weight. SHBG is a protein that binds testosterone in the body and prevents its activity with the androgen receptor. As men gain weight, fat cells accumulate and are able to convert more testosterone into estradiol (predominate form of estrogen in men), promoting a low testosterone environment. Breaking this cycle can be achieved by testosterone replacement therapy, assisting in weight loss, improving metabolism, reducing fat cells and aromatase activity. Testosterone replacement therapy has been proven in several clinic studies to reduced waist circumference, improve insulin sensitivity increase lead body mass (muscle) and improve the symptoms of metabolic syndrome (hypertension, hyperlipidemia and obesity). Clinical studies convey a testosterone therapy duration of 6-36 months can enhance weight loss and reduce waist circumference in men. Average testosterone replacement therapy dosages can range from 0.75cc to 1cc of 200mg/cc of testosterone cypionate weekly. Adding an estrogen blocker such as aromatase can assist in lowering elevated estrogen levels often present in obese and over weight men. Aromatase inhibitors such as Arimidex will also to raise testosterone, by preventing its breakdown. Testosterone replacement therapy (TRT) will also improve energy, glucose utilization and promote mental well being that aids in living a healthier lifestyle. Testosterone replacement therapy provide many benefits in obese and overweight men. Men who have low testosterone and desire to lose weight should consider having their testosteron levels checked and consider TRT if levels are low. To learn more about Low-T, Weight Loss and Testosterone Therapy for physique enhancement, contact a professional at REGENXHealth.com today.

Keywords: Testosterone exercises, HITT, Gym exercises boosting testosterone levels, How to raise testosterone levels in the gym, Workouts to increase testosterone levels, Androgen Receptor, IGF-1, Growth Hormone, Type 1 and T2 Muscle Fibers, Testosterone and Muscle Growth, Size and Strength Enhancement. The Best Testosterone Boosting Workouts and Exercises: A comprehensive review of the best gym exercise to raise testosterone levels. · HITT (High Intensity Interval Training) · Compound Movements · Resistance Training Exercises Resistance exercise is potent stimulus that can enhance muscle performance and fuel muscle growth. Exercise and resistance workouts cause muscle growth by inducing muscle fatigue, muscle repair and up-regulation of the androgen receptor (AR) with muscle . Strain on skeletal muscle due to lifting weight causes a cascade of events that activates the endocrine system to remodel damaged muscle fibers and synthesize new proteins that lead to muscle repair, growth and enhanced strength. Principle to this process of muscle growth are the hormones testosterone, insulin like growth hormone (IGF-1) and growth hormone. The principle hormone responsible for muscle growth is testosterone. Testosterone has been shown to increase muscle size and circumference by directly enhancing Type 1 and Type 2 muscle fiber (myofiber) size and growth. Testosterone causes muscle growth, strength and size my activating the androgen receptor in muscle tissue. Activation of the androgen receptor in muscle tissue by testosterone causes the following: 1) Testosterone causes an increase in glucose transport and deposition into the muscle tissue and glycogen synthesis for muscle use. This process is important for the muscle to fuel itself for repair, growth and obtain increases in strength. 2) Testosterone promotes protein synthesis, preventing catabolism, in muscle tissue. Protein synthesis is necessary to rebuild myofibrils and myofibers the structural component of muscle. New muscle tissue is added during muscle remodeling and repair from strenuous exercise and lifting thereby inducing muscle growth. Within as much as 30 minutes of exercise the acute phase response to resistance training can stimulate testosterone elevation and activation of the androgen receptors (AR) in skeletal muscle. Paramount to raising testosterone exhibited during and after gym workouts are the following: the type of exercise, duration of exercise, rest between exercise, nutritional intake before and during exercise, intensity and volume (weight) involved during exercise. Consider the following to asssit in boosting testosterone in the gym. When performing exercises that will boost testosterone, consider the following: 1) High intensity, – rapid succession movements moderate weight. 2) Exercises that involve multiple muscle groups 3) Exercises that involve the largest muscle groups in the body such as Back, Quadriceps, Hamstring, Shoulders/Trapezius 4) Compound movements that recruit multiple muscle groups to perform an exercise (squats, bench press, deadlift…etc.) Compound Movements That Raise Testosterone Levels · Bench Press (Barbell or Dumbbells) · Squats · Seated or Bent over Rows · Overhead press (Dumbbells or Press Machine) · Hack Squats · Deadlifts · Kettlebell exercises · Barbell Clean and Jerk · Heavy Battle Ropes High Intensity Interval Training, also known as HITT, provides condensed volumes of exercise to illicit an increase in muscle power, cardiovascular, and metabolic health. In a study by Hayes et.al, HITT exercises can improve testosterone levels by 17%. HITT is training technique that involves giving 100% maximal effort during short runs of training, followed by short recovery and rest periods. Nutrition Intake suggestions to replenish glycogen stores after resistance training and enhance muscle growth and recovery. 1) Carbohydrate intake within 4 hours after exercise 2) Caffeine ingestion ( 3-8mg/kg) 3) Addition of protein to carbohydrate can improve glycogen deposition Nutrition Intake suggestions to replenish glycogen stores during high intensity resistance training. 1) 30-60gram of carbohydrates/hr in a 6-12 fluid ounces during workout of high intensity 2) Adding protein to the solution can assist in increasing performance, reduce muscle damage, and promote glycogen synthesis ( Kersick CM et.al.) 3) Consider repetitions of 8-12 repetitions, 3-6 sets targeting major muscle groups- promotes improvement in glycogen store with the above nutrition intra workout nutrition recommendation. 4) Use of Amino Acids 10grams, enhances and stimulates muscle protein synthesis. Nutrition before sleep to enhance muscle growth and protein synthesis 1) Consuming 30-40grams of protein can enhance muscle protein synthesis and improve basal metabolic rate while sleep. To learn more about raising your testosterone naturally visit with a REGENX Health provider today at REGENXHealth.com. Hayes LD, Herbert P, Sculthorpe NF, Grace FM. Exercise training improves free testosterone in lifelong sedentary aging men. Endocr Connect. 2017;6(5):306-310. doi:10.1530/EC-17-0082 Kraemer WJ, Ratamess NA, Nindl BC. Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise. J Appl Physiol (1985). 2017 Mar 1;122(3):549-558. doi: 10.1152/japplphysiol.00599.2016. Epub 2016 Nov 17. PMID: 27856715. Kerksick CM, Arent S, Schoenfeld BJ, et al. International society of sports nutrition position stand: nutrient timing. J Int Soc Sports Nutr. 2017;14:33. Published 2017 Aug 29. doi:10.1186/s12970-017-0189-4

A Review of the treatment options for men who want to stop Testosterone and other Anabolic Steroids safely. Keywords: Testosterone, Anabolic Steroids, Anabolic Steroid Side Effects, HCG, Clomid, FSH, LH, recombinant FSH, Treatment of Testosterone Side Effects, Anabolic steroids are well known to be misused in competitive sports. Now more than ever, anabolic steroids are becoming more of a “social drug” and used among gym athletes to improve lifestyle and physique appearance. The vast majority of these illegal anabolic drugs are obtained without a doctor’s prescription, without a valid medical indication and without proper physician oversight and follow up management. While testing of athletes in professional sports has provided a unique insight into their widespread use, in the private life of gym goers who are not subject to rigorous testing provided by organized sporting authorities, little is known about health risks of anabolic steroids. It is reported that 50% of all illegal anabolic steroids are obtained without a valid medical prescription or indication. The majority of medication obtained in a such matter, contain ingredients that do match the label according to several studies. In a study conducted in the Netherlands, an internal medicine department established an anabolic androgenic steroid clinic to better study young patients taking steroids and the associated health risks. 160 male patients visited the clinic between May of 2011 and May 2016. The average age of patients was 34, and all were strength athletes. Each male patient presented to the clinic having been on a median steroid cycle of 6 -18 weeks. The theory behind cycling medication is too allow the body to rapidly build muscle and strength then recover from the toxicity of anabolic steroids. Most common steroids used by young male athletes included testosterone, nandrolone and trenbolone. The most common side effects reported with anabolic steroid use included the following: o Acne o Gynecomastia o Testicular atrophy o Agitation o Mood changes o Decrease in sex drive o Erectile dysfunction o Fatigue o Insomnia o Addictive behavior o Syncope o Sleep Apnea o Delusions o Subfertility o Infection at injection site (most sever complication experience by users) o Alopecia o Fluid retention o Pruritus Most male patients self-treated their side effects with a variety of medication that most commonly included clomiphene citrate, anastrozole, HCG and tamoxifen. These medications in particular were used for 2-4 weeks post cycle and were used to reduce increases in estrogen, reduce gynecomastia, improve testicular testosterone production and raise fertility potential. Treatment of Anabolic Steroid Side Effects Persistent and Painful Gynecomastia ( Male Breast Enlargement) Tamoxifen 20mg daily. Surgery may be recommended if pain is persisting and failure of medical therapy to provide resolution of symptoms. Post Anabolic Androgenic Steroid Hypogonadism The persistence of low testosterone can occur in men who have abused or taken anabolic steroids for a prolonged period of time. Anabolic steroids can suppress natural testosterone production from the testicles and pituitary function. Goals of therapy to are to improve testicular production of testosterone with HCG, recombinant FSH, and Clomiphene Citrate (Clomid). Medication is aimed to restart the hypothalamo-pituitary- gonadal axis. Tamoxifen can also be used and acts as an estrogen antagonist on the hypothalamus and pituitary. Tamoxifen can stimulate LH and FSH to improve endogenous testosterone production. HCG 1500 IU( or even large doses) twice weekly is often prescribed in such clinical cases, and can improve endogenous testosterone levels. Restoring Spermatogenesis and Testicular Atrophy To improve sperm function, quantity and quality and improve testicular volume in men who have used anabolic steroids or testosterone, the use of HCG can improve such a condition. HCG is a naturally occurring protein, produced by the human placenta, and mimics the actions of luteinizing hormone (LH). LH is secreted by the pituitary and is responsible for testicular production of testosterone and necessary for proper sperm maturation. High doses of HCG are often prescribed to men who need to improve sperm count post anabolic steroids in comparison to the HCG dosage men take to maintain sperm function while on anabolic steroids and testosterone. Typically, men who are prescribed testosterone and desire to maintain testicular volume and fertility are provided HCG 500 IU three times weekly. There a variety of studies that have used variable amounts of HCG to induce spermatogenesis in post cycle conditions. Studies by Boulous etl. al., 2003 used HCG 1500-3000 IU twice weekly, while other studies Farhat et. al., investigated using HCG 1500 -5000 IU three times weekly. Typically, if no improvement in sperm count is witnessed by 3 months the addition of rFSH 75 IU three times weekly can be considered. There is no gold standard or guideline on how to improve or prescribe HCG for men who desire to improve spermatogenesis post cycle of anabolic steroids. Yet the HCG dosages mentioned prior, pregnancy rates approached 56%, and in some cases 72%. Times for recovery of full sperm production and fertility can take up to 2 years. For More information visit with an expert at REGENXHealth.com The following content is not intended or should be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Smit DL, de Ronde W. Outpatient clinic for users of anabolic androgenic steroids: an overview. Neth J Med. 2018;76(4):167.

Factors that influence testosterone injection discomfort. An easy guide to make testosterone injections virtually pain free The most potent form of testosterone is commonly given by an intramuscular injection. Intramuscular injections of testosterone can cause local skin irritation, slight pain at the injection site, possible intravascular delivery of medication and possible scarring at the skin level. Studies have shown that the medium that testosterone is suspended, the oil base, can account for the local skin irritation. In a study published in the Asian Journal of Urology by Sartorius et. al. Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate, the discomfort around the injection site after an IM injection was found to be less severe in men who are older and more obese. Age and body weight are the two predominate factors that influence a painful injection experience. While it can be expected that any intramuscular injection will cause some degree of discomfort, the severity, duration and experience by each patient will vary. In a study by O Svendsen et. al. Intramuscular injections and muscle damage: effects of concentration, volume, injection speed and vehicle, it was revealed that small volume of concentrated solution vs larger volume of. Less concentrated solution produced less muscle damage. The speed by which an injection is given into the muscle was not factor. At REGENX Health we advise all patients to perform the following maneuver to reduce injection site discomfort during and after a testosterone injection. Prior to injecting testosterone into the gluteus muscle use a large alcohol pad and prep the injection site by rubbing the alcohol pad on the skin for 1 minute. This maneuver causes a local skin desensitization. The skin may appear a little red prior to to the injection and this is normal. Next, inject testosterone at the prepped site and remove needle. Lastly, use an alcohol pad to again rub the injection site. For more information and to get started on testosterone therapy visit with the experts at RegenxHealth.

Keywords: Clomid, HCG, Fertilty, Sperm Production, TRT, Testosterone Therapy Low-T Low-T, also known as hypogonadism, is medical condition defined as having a low testosterone level and symptoms of low sex drive, erectile dysfunction and low energy. Young men who often choose intramuscular testosterone cypionate or enanthate as treatment options for Low-T, may be unaware that testosterone can reduce a man’s sperm count. Testosterone replacement can be considered an infertility drug for men given its effect to lower sperm count to zero (azoospermia). A study published recently in the Journal of Urology by Thiago et. al. evaluated the use of serum 17-Hydroxyprogesterone to monitor and assess intratesticular testosterone necessary for proper spermatogenesis (sperm production). Men on TRT will experience a decrease in intratesticular testosterone. Testosterone within the testicle is necessary for sperm production. Evaluating 17-Hydroxyprogesterone may provide insight and monitoring of fertility while a man is on TRT. For men who are using clomiphene citrate or human chorionic gonadotropin (HCG) either as monotherapy or with TRT, monitoring 17-Hydroxyprogesteron levels can be of clinical value to understand the intratesticular testosterone environment that is suitable for sperm production. As detailed by the study, for young men who desire to be on TRT, measuring 17-Hydroprogestoenre can identify men who may have an underlying impaired sperm production anomaly. For more information on testosterone therapy and to get started on therapy from the experts, visit us at REGENXHealth

Keywords: Estradiol, E2, Arimidex, Tamoxifen, Clomid, Testosterone, Obesity, Male Breast Tissue, Testosterone Enanthate, Liposuction, Plastic Surgeon, Gynecomastia is an enlargement of male breast tissue and can be secondary to a variety of medical conditions. Medications such as statins, proton pump inhibitors, Lasix diuretics and HIV medication are associated with enlargement of male breast tissue. Nutraceuticals, alcohol and marijuana use can enlarge the fatty tissue of the male breast. Many men who are planning to undergo testosterone replacement therapy (TRT) do ask about the risk of getting male breast tissue growth while on therapy. Gynecomastia is an estrogen mediated phenomenon. In men who are on high dose anabolic androgenic steroids the development of gynecomastia is 20-30%. Men who undergo TRT may experience a rise in the E2 ( Estradiol) levels and subsequent enlargement of breast tissue. Gynecomastia is often more common in men who are undergoing testosterone replacement with testosterone enanthate compared to testosterone cypionate. The most significant risk factor for gynecomastia development is a low testosterone level and obesity. For men with Low T and pre existing gynecomastia, testosterone therapy can improve gynecomastia by altering the estradiol/ testosterone ratio. For male patients who find themselves observing male breast enlargement, the addition of Arimidex (anastrozole), to reduce estradiol levels can prevent gynecomastia while on TRT. For patients who develop or have preexisting gynecomastia, combination use of Arimidex and Tamoxifen is useful to shrink and target male breast tissue. Tamoxifen is also useful to combat the discomfort that accompanies enlargement of male breast tissue. The standard dosing is often 10-20mg/day for three to six months. Pain improvement is often experienced in the first month. 90% reduction in male breast size is often experienced by 3-6 months of therapy. Gynecomastia refractory to medical treatment may necessitate surgical intervention with a plastic surgeon to perform a liposuction with possible mastectomy. Male patients who are on a SERM, such as Clomid (Clomiphene Citrate), will experience a rise in Estradiol concomitantly with a rise in total testosterone. Use of Arimidex can be advised during Clomid use as well. In men who are on Testosterone therapy, commonly an estradiol level rise above 40, should prompt the clinician to consider the use of an anti-estrogen. Elevated estradiol levels can negate the effects of an elevated testosterone level. To obtain testosterone therapy from the experts visit REGENX Health for more information.

Keywords: Fertility, Sperm Function, sperm banking, infertility, Clomid, HCG, Anastrozole, Many patients will ask “How long does it take after stopping testosterone replacement therapy for my fertility to return to normal?” The answer depends on several factors. First, how long has the patient been on testosterone replacement therapy (TRT). A longer duration of TRT, higher BMI and a higher dose of TRT can suppress sperm production more so than a shorter course or lower dosage of testosterone therapy. Second, is patient age. Men who are older and who are undergoing TRT can expect a longer sperm recovery time compared to a younger male. Third, during TRT the use of HCG can maintain spermatogenesis and testicular volume ( ie. prevent testicular shrinkage) . Using HCG in combination with testosterone can reduce the chance of infertility during TRT. After a man starts testosterone replacement therapy, it takes approximately 2.7 months for the total sperm count to be reduced. After testosterone therapy cessation, it can often take 6 months before the total sperm count returns to normal. Spontaneous recovery of fertility is common after stopping testosterone therapy, yet this process can be expedited. To expedite sperm recovery during or after testosterone therapy, men have several medication options that include: · Selective Estrogen Receptor Modulators (SERMS) such as Clomid (Clomiphene Citrate) · Aromatase inhibitors (Anastrozole) o Effective with testosterone to estradiol ration less than 10 · Human Chorionic Gonadotropin (HCG) · Follicular Stimulating Hormone (Recombinant FSH) o Directly stimulates the pituitary gland to stimulate sperm production in the testis o Very expensive It is important to know that testosterone can be considered an infertility drug for men. Men who are trying to conceive with their partner or who may be looking to have a child in the near future, should consider testosterone replacement alternatives that increase testosterone and maintain sperm function. Many younger patients who desire testosterone commonly ask if sperm banking/preservation is a viable option to consider while obtaining testosterone therapy. While this approach may be expensive, let alone the price of in-vitro fertilization if the sperm were to be utilized, sperm banking is not necessary as fertility will commonly return to normal. To learn more about Testosterone therapy and fertility or to increase your testosterone while maintaining fertility contact RegenxHealth today online.

The difference between testosterone esters. Is there a significant difference between testosterone enanthate and testosterone cypionate? Is there a between Grape Seed oil and Cotton Seed oil as a suspension base? Optimizing Testosterone: Know Your Testosterone Injectables: Testosterone Cypionate, Enanthate, Undecanoate, Propionate, Sustanon and Aquaviron. Sustanon is a well-known medical drug to treat men with low testosterone levels. Sustanon is an oil base injectable anabolic steroid, similar to testosterone cypionate or testosterone enanthate. Sustanon, however, is composed of a combination of four testosterone esters. Each testosterone ester that comprise the medication Sustanon has a different half life and therefore may promote a more steady state release of testosterone from the injection site. i) Testosterone propionate, ii) Testosterone phenylpropionate, iii) Testosterone isocaproate iv) Testosterone decanoate Much of the testosterone that is prescribed today is in the form of a testosterone ester. An ester is compound that is added to testosterone to prolong its half life and viability in the body. Pure testosterone, if injected, has a very short half-life, lasting in the body for only a few hours. Aquaviron is a testosterone suspension (unesterified testosterone suspended in a water base) and must be injected daily in order to maintain a steady concentration and elevated level of testosterone in the body. Aquaviron has the consistency of water and can be injected into the body via a small 27-guage or 28-gauge needle. Daily injection to testosterone would not only be uncomfortable but tedious to perform. Therefore, esters are added to testosterone to prolong the half-life and slow the release of testosterone from the injection site allowing some injections to last up to 10 weeks. There are a variety of testosterone esters and all have different half-lives. Examples of testosterone esters include testosterone enanthate, cypionate, acetate, propionate, phenylpropionate, isocaproate, caproate, decanoate, and undecanoate. Sustanan is blend of 4 testosterone esters. Sustanon is prescribed outside the United States and combines both fast acting and slow acting testosterone esters (long and short half-lives). Sustanon is proclaimed to provide a more “even” level of testosterone administration without the peaks and troughs found with short acting testosterone esters. Aveed ®, also known as testosterone undecanoate, requires only 5 injections per year to maintain a steady state of an elevated testosterone level in men with Low T. Testosterone undecanoate will slowly release testosterone for up to 10 weeks. Aveed ® must be given in a doctor’s office and cannot be used for home use and is available in the United States. Testosterone Enanthate and Testosterone Cypionate are the most prescribed forms of testosterone in the United States today. They both release testosterone over an 8-10-day duration and achieve a 400% increase in testosterone above baseline within 24-36 hours after injection. Most patients will inject Testosterone Cypionate or Testosterone Enanthate once a week or every two weeks. The more experienced patient may inject testosterone twice weekly to achieve more supra-physiologic level of testosterone. Both Testosterone Cypionate and Testosterone Enanthate tend to be interchangeable in medical practice, and very seldom can patients feel any difference between the two forms of testosterone. Testosterone Cypionate and Testosterone Enanthate are suspended in an oil base consisting of Cotton Seed Oil or Grape Seed Oil. While most novice patients do not have a preference between the suspension oil, more experienced patients may prefer Grape Seed oil provided it may be less viscous and have less of allergic response compared to Cotton Seed Oil. There is not scientific evidence or studies that would advocate either oil base over another. Choosing the right testosterone formulation is imperative to obtain the desired results while on TRT. To optimize your testosterone replacement therapy regimen or to begin therapy under the guidance of a certified urologist consult with a Regenx Health specialist today. For more information about choosing the right testosterone preparation visit RegenxHealth.com.

What are Androgenic Steroids? What are the indications and uses for Anavar in men's health? What are the side effects of Anavar? How does Anavar work? What is the difference between testosterone and Anavar? How does Anavar effect testosterone production? Keywords: Oxandrolone, Anavar, Anabolic Steroid Hormone, AAS, Testosterone and Oxandrolone, SARM, Selective Androgen Receptor Modulator, Anabolic Androgenic Steroid, Sarcopenia, Gaining Muscle Mass, IGF-1, Insulin-Like Growth Factor. What are Anabolic Androgenic Steroids? Anabolic Androgenic Steroids (AAS) are a type of steroid hormone developed to promote anabolism; the process of building and synthesizing molecules in the body. All AAS are derivatives of the steroid hormone testosterone. AAS were designed to improve upon testosterone's anabolic effect while minimize unwanted androgenic effect in treating patients with catabolic medical conditions. The anabolic effect of AAS are to promote protein synthesis through the efficient use of amino acids, prevent protein breakdown, retain nitrogen and build skeletal muscle. Androgenic effects are those related to puberty such as male pattern baldness, deepening of the voice, facial hair growth, increase sebaceous gland excretion. AAS, such as Anavar, have a high anabolic activity (high anabolic: androgenic ratio of 10:1) compared to testosterone (anabolic: androgenic ratio of 1:1). What is Oxandrolone (Anavar)? Oxandrolone a unique oral anabolic steroid hormone that is also known as Anavar. Anavar was first synthesized in 1962 and has been used in the medical treatment of catabolic disorders for over 30 years. Anavar is unique because it has great oral bioavailability (can be taken my mouth) and is resistant to liver metabolism. Anavar also does not get aromatized into estrogen compared to testosterone. The primary use of Anavar is to prevent frailty and the loss of muscle mass due to aging (sarcopenia) and other related catabolic clinical disorders such as HIV -related muscle waiting, severe burn injuries, trauma after surgery and hepatitis. Anavar has been shown to: 1) Decrease visceral fat and total body fat 2) Increase protein synthesis in skeletal muscle 3) Increase dietary energy and protein intake 4) Increase nitrogen retention 5) Increase muscle function, growth, strength and physical activity level 6) Substitute for the natural loss of androgen and estrogen hormones How does Oxandrolone (Anavar) work? Anavar increases muscle mass in three ways 1) Inducing protein synthesis in the body 2) Up regulating the androgen receptor in skeletal muscle. 3) Increasing IGF-1 (insulin-like growth factor) Anavar given to healthy men, has been shown to increase protein synthesis by as much as 44% and improve effects of resistance training. What are the indications and usage for Anavar (Oxandrolone)? Anabolic Androgenic Steroids are indicated in patients chronic wasting conditions (the loss of muscle mass) to prevent frailty. Such conditions include sarcopenia, AIDS related muscle wasting, severe burn injury, trauma following surgery and other catabolic disorders. Anavar is approved by the FDA for the treatment of patients with prolonged use of corticosteroids to prevent protein catabolism and has been used to promote weight gain after extensive surgery, during chronic infectious states, or after severe trauma. How is Oxandrolone (Anavar) absorbed? Anavar is an oral medication that is absorbed across the gastrointestinal tract. Peak serum concentrations of Anavar occur within 1 hour after ingestion. In the body, Anavar is 95% bound to protein, which may contribute to the steroid’s stability and resistance to breakdown by the liver. How is Oxandrolone (Anavar) metabolized (broken down)? Unlike other anabolic steroids, Anavar is rather resistant to liver biotransformation. Approximately 28% of Anavar is excreted in the urine unchanged. What is the difference between Testosterone and Oxandrolone (Anavar)? Anavar has a much higher potential to promote anabolic effects on the human body such as an increase muscle size, strength, nitrogen retention, reduce fat deposition and induce protein synthesis compared to testosterone. While testosterone will also promote androgenic affects, Anavar was designed to lessen the unwanted androgenic effects and promote more anabolic properties. Anavar has much higher anabolic activity compared to testosterone. Anavar has an anabolic: androgenic ratio of 10:1 and a higher steroid protein activity level (SPAI) of 2.8. Testosterone on the other hand has an anabolic: androgenic ration of 1:1 and an SPAI of 1. How does using Oxandrolone (Anavar) effect Testosterone production? Anavar usage will decrease the natural pituitary axis necessary to maintain testosterone production. Men who use Anavar will experience a decrease in LH, FSH, SHBG and total and free testosterone. More commonly in men with chronic muscle wasting conditions or HIV wasting, Anavar is combined with testosterone. Anavar usage has been shown to reduce sex hormone binding globulin (SHBG). Reduction in SHBG reduction increases the amount of free testosterone (active) in the body. Safety Information What are the side effects of Oxandrolone (Anavar)? The most common side effect of all AAS is liver toxicity and cholestatic jaundice, among others. Such adverse effects on the liver are demonstrated in patients utilizing high dosages of Oxandrolone for greater than 1 yr and concomitant use with other anabolic agents. No evidence suggests that short term use of Oxandrolone had led to the development of liver function impairment. Other side effects of Anavar in males include: Inhibition of testicular function (infertility) Testicular atrophy Oligospermia Impotence (Erectile Dysfunction) Priapism (Prolonged Erection) Epididymitis Bladder Urgency and Frequency (worsening of lower urinary tract symptoms) Gynecomastia Acne Bleeding in patients currently on anticoagulant therapy Insomnia Decreased glucose tolerance Oxandrolone (Anavar) and Hepatotoxicity All Anabolic Androgenic Steroids will impart a hepatic affect. Hepatic dysfunction has been shown to occur in men who have taken Anavar for greater than one year continuously. Hepatic dysfunctions as a result of Anavar use can include elevations in liver function enzymes, Peliosis hepatis, adenomas and concerns have been made for hepatocellular carcinoma. There has not been sufficient evidence to suggest that short term, less than 3 months of use of Anavar, will lead to serious forms of hepatotoxicity. What is Peliosis Hepatis? Peliosis Hepatis is a condition in which blood-filled cysts present in the liver and sometimes the spleen as a result of Anavar usage. The cysts can grow and accumulate within the liver, replacing normal hepatocytes that can lead to liver failure and dysfunction. Withdrawal of the medication can halt cyst growth and cyst regression. Who should not take Oxandrolone (Anavar)? 1) Any male with known history of or suspected prostate cancer or male breast cancer. 2) Hypercalcemia 3) Renal Dysfunction What medications are contraindicated with Oxandrolone (Anavar) use? Anticoagulants Anabolic steroids, such as Anavar, can increase the activity and sensitivity of oral anticoagulants (blood thinners). Oral Hypoglycemic Medications Adrenal Steroids or ACTH For more information visit RegenxHealth.com

The differences and benefits of Nandrolone Decanoate compared to Testosterone Replacement Keywords: DECA, Anabolic Steroids, Testosterone Therapy, Nandrolone Decanoate. In the aging male population, the loss of muscle mass can be accentuated by a natural decrease in anabolic hormones. Different anabolic therapies are available to improve skeletal muscle density, muscle strength and size to reduce fragility, risk of fall and enhance activities of daily life. Anabolic and androgenic agents such as Nandrolone Decanoate (Deca) and Testosterone have shown to consistently increase skeletal muscle tissue and heighten the effects of resistance training. Both testosterone and Deca increase the size and number of myofibrils, the structural component of muscle tissue. In a multi-center randomized placebo-controlled study, Gold et. al evaluated the differences in muscle mass and strength in 303 men who received 150mg of Nandrolone Decanoate vs 250mg of Testosterone vs placebo intramuscularly every 2 weeks for 12 weeks. The men who received 150mg of Nandrolone Decanoate administered every two weeks were found to report improved recovery after resistance exercise and an increase in measured lean muscle mass compared to the administration of 250mg of testosterone twice weekly. Most importantly, the addition of resistance exercise to Nandrolone Decanoate therapy improved muscle quality and strength by as much as 55%. Resistance exercise may improve the effect of anabolic hormone therapy by changing the architecture of the muscle (compacting muscle fibers, improving neuromuscular adaptations to resistance and changing the ratio of type I & type 2 muscle fibers.) The study also quelled the concerns that anabolic / androgenic agents cause significant increases in serum lipids profiles and liver function tests. These findings were not witnessed in the current study. In men, with muscle wasting conditions, growth hormone therapy is often used to improve fat free mass. The study noted above demonstrates the alternatives to growth hormone therapy to achieve similar outcomes. DECA has both the characteristics of testosterone, but much greater activity towards stimulating muscle growth and improving recovery after strenuous resistance exercise. DECA is used clinically to treat patients with burns, radiation therapy, sarcopenia and muscle wasting conditions. Deca has a long half and binds with a strong affinity to androgen receptors. Deca, unlike testosterone, does not undergo conversion to DHT and has less effect on hair follicles. Deca is often provided with testosterone to prevent suppression of the hypopituitary gonadal axis and maintain certain male physiologic processes. Nandrolone Decanoate is a type II anabolic androgenic steroid. Anabolic steroids were developed in the 1930’s and by the 1980’s wide spread use was found among elite athletes to enhance muscle size, growth and performance. Currently, it is estimated that over 4 million individuals in the United States use some form of anabolic steroids, and not just elite athletes. The majority of individuals obtain such medication from non-licensed medical personal. Therapy is often not monitored and anabolic steroid usage is considered a global public health problem.

1) Improvement in Sex Drive, Energy and Muscle Mass / Strength 2) Social Energy and Motivation to complete tasks 3) Improvement in fat free mass, reduction in waist circumference Keywords: What does testosterone do to me, What will I expect on Testosterone Therapy, What will I feel on TRT, High dose Testosterone Therapy, Weight Loss, Muscle Size, Muscle Strength, Mood, Behavior, Focus, Energy. Men can feel the effects of testosterone replacement therapy (TRT) in as little as 2-4 weeks. In most men effects of TRT are felt within 3 months. The most commonly improved symptoms enhanced by TRT include improvements in energy, sex drive, muscle size, strength, fat loss and improved mood. In a clinical study by Straftis et. al., Sex, Energy, Well- Being and Low Testosterone: An Exploratory Survey of U.S. Men’s Experiences on Prescription Testosterone, men on TRT were asked the following questions: Since taking prescription testosterone, have you noticed any changes in your motivation at school/work?” 98% of men found testosterone replacement to have a positive improvement in their ability to focus and motivation for work tasks. While other studies confirm testosterone to be linked to dominance motivation and status striving, a performance enhancing effect, testosterone heightens motivation to complete tasks. Describe any changes you have noticed in your family life, since taking testosterone” 58.1 % found improvement in social energy, energy used for quality of life activities and family activities. What did you perceive as the benefits of testosterone? Most men in the study found a benefit with testosterone replacement, with benefits mostly focused around energy, performance, well-being, fat loss, muscle growth and an overall feeling of well-being. In survey of 110 men published by Gilbert K et. al., the major symptoms experienced by men with Low T most notably include low energy, fatigue and naps after work, low sex drive, weak erections, and decreased strength. Of the perceived benefits from testosterone replacement therapy were improved sexual function and desire, increased daily energy and well-being. High Dose Testosterone For men who receive high doses of testosterone significant increases in muscle arm size, triceps size and quadricep size has been reported in clinical studies. A study published in the New England Journal of Medicine, The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in Normal Men by Bhasin et.al., found men who were given 600mg of testosterone enanthate weekly paired with an exercise routine were found to have a significant increase in fat free mass, increase in diameter of quadriceps and arms and improvement in strength ( measured by an increase in bench press weight by 22% percent and squatting exercise increase by 38%). There were no changes in mood, behavior, or aggressiveness in men who were provided supraphysiological doses of testosterone. Total testosterone measurements in male subjects after administration of 600mg of testosterone enanthate were 2828 +/- without exercise and 3244 +/- with an exercise routine. No immediate toxicities were observed during the 10-week study duration, yet long term studies are necessary to provide reliable safety data. While this study provided insights into the beneficial effects of supraphysiological dosages of testosterone and safety, it is well known that performance and bodybuilding athletes take even higher dosages of testosterone. The term “stacking” is often utilized by athletes who use multiple androgenic steroid medications to achieve a desired performance outcome and/or physique. Stacking anabolic steroids can achieve supraphysiological levels of testosterone. Finally, there was no documented cases of aggressive behavior or tendencies with high dose testosterone usage. This is supported in other clinical studies that aggression is not correlated with wither testosterone levels or having used testosterone therapy.